Objetivo: avaliar o impacto da nefrite lúpica e suas complicações nos resultados gestacionais. Métodos: avaliamos retrospectivamente 76 gestações em 63 pacientes com lúpus eritematoso sistêmico (LES). Resultados: a hipertensão arterial estava presente como complicação clínica em 23 (30%) gestações. Vinte e sete (36%) gestações ocorreram em 19 pacientes com nefrite. Encontramos um número significativamente mais elevado de óbitos fetais quando avaliamos todas as pacientes com nefrite em comparação com aquelas sem nefrite (37% e 12,2%, respectivamente [p=0,019]). Conclusões: além da atividade de nefrite e do diagnóstico de nefrite propriamente dito, tiveram relação com pior sobrevida fetal a associação da síndrome do anticorpo antifosfolipídeo ou detecção de um dos anticorpos relacionados, a presença HAS e insuficiência renal (mesmo em suas fases iniciais).

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Objective Tumor necrosis factor-alpha (TNF-α) is an important inflammatory cytokine. 99mTc-anti-TNF-α antibody scintigraphy has proven to be a viable alternative to MRI in specific cases. The objective of this study was to evaluate the performance of scintigraphy with 99mTc-anti-TNF-α in the identification of inflammatory foci in individuals diagnosed with rheumatoid arthritis using MRI as the gold standard. Methods This cross-sectional, descriptive and analytical-qualitative clinical study compared the performance of 99mTc-anti-TNF-α scintigraphy with that of MRI with intravenous administration of gadolinium (used as the gold standard) and a clinical examination (Disease Activity Score 28) in 220 joints of 20 patients with a diagnosis of rheumatoid arthritis and one healthy control. Results The concordance of scintigraphy with MRI in individuals with a diagnosis of rheumatoid arthritis was 79%. The accuracy, sensitivity and specificity of scintigraphy for distinguishing between inflammatory and noninflammatory sites were 92, 89, and 93%, respectively. No adverse reactions to the examinations were reported. Conclusions Scintigraphy with 99mTc-anti-TNF-α was well-tolerated and had a good ability to distinguish between inflammatory and noninflammatory lesions in patients with rheumatoid arthritis.

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