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By midresidency, these pediatric residents have had many personal and professional experiences with death. Residency training programs must provide venues for residents to address bereavement, facilitate the integration of these experiences, and provide time to attend funerals.

Neutrophils were preincubated with 17 betaestradiol and progesterone to determine the effects of these hormones on chemotactic peptidestimulated superoxide anion (02-) generation and degranulation. At pharmacologic levels 17 beta-estradiol was more active than progesterone with respect to inhibition of 02-generation as well as degranulation. An increase of preincubation time from 5 minutes to 25 minutes increased the percent inhibition. When 17 beta+stradiol and progesterone were combined at levels which approximate those measured during gestation, there was small but significant inhibition of 02-generation. Dexamethasone at equal molar concentration inhibited 02-generation only after 25 minutes of preincubation and at no time reached the level of inhibition attained by either of the sex hormones alone. Both estradiol and progesterone at pharmacologic levels significantly inhibited betaglucuronidase and lysozyme release, whereas dexamethasone did not inhibit degranulation despite prolonged preincubation. Neutrophils isolated from women during various phases of the menstrual cycle and during the -