TW4-response indicates the probability of achieving SVR to currently used DAA-based therapy in HCV genotype 3-infected individuals with cirrhosis. This finding may be useful to tailor treatment strategy in this setting.

with all the patients, regardless of the levels of CD4 lymphocytes and the symptomatology. Purpose Persistence: time a patient remains with a treatment frome the beginning until the interruption, regardless of the reason. Aim of this research: comparison between the patients' persistence who different ART. Material and methods Descriptive, transversal and retrospective research that includes all the patients who have started an ART for HIV, 2013-10 October 2018, and who have suffered a change in the therapy.Variables: starting date, initial treatment, changing date and reason for the change. Analysis: SPSS Statistics. Results Six-hundred and sixteen patients have started ART and 186 (30.2%) of them have changed it.Fifty-one (27.4%) patients started ART with single tablet regimens (STRs), 40 (78.4%) started with Tenofovir/Emtricitabine (TDF o TAF/FTC) and 11 (21,6%) Abacavir/Lamivudine (ABC/3TC). Thirty-two 62.7%) were with an integrase inhibitor (INI) as a third drug, and 19 (37.3%) with no analogous (ITINN).One-hundred and thirty-five (72.6%) patients started with multiple tablet regimens (MTRs), 115 (85.2%) TDF/FTC and 16 (11.8%) ABC/3TC. Seventy-two (53.7%) were with protease inhibitor (IP) as a third drug, 34 (25.4%) ITINN and 28 (20.9%) INI.The median survival for STRs was 229 days (95% CI 146.0 to 311.9) and 164 for MTRs (95% CI 87.8 to 240.2), no statistically significant differences. Regarding the third drug, the median survival with INI was 103 days (95% CI 65.0 to 140.9), 241 days with IP (95% CI 162.1 to 319.9) and 265 days with ITINN (95% CI 162.1 to 367.9). Between INI-IP and INI-ITNN, there were statistically significant differences.One-hundred and five (56.5%) patients changed their treatment because of toxicity, 48 (25.8%) patients simplification, 19 (10.2%) patients virologic failure, seven (3.8%) patients due to interaction with their home treatment and seven (3.7%) other causes. One-hundred and five patients changed ART by toxicity ( 39of them (37.1%) had as a third drug IP, 37 (35.2%) ITINN and 29 (27.6%) INI) In 2013-2015, 20 (16.8%) patients started STRs and in 2016-2018, 31 (46.3%) patients started STRs. Conclusion ART combinations with STRs have a longer survival in the treatment and in patients with IP as a third drug, a greater survival is observed. The main cause of ART in naïve patients is toxicity. There was a gradual rise in the use of STRs throughout the years studied.

prior to the patient leaving the PICU, and paediatric CCPs perform discharge medication reviews. By involving the PICU team in the medication discharge process, we aim to improve the quality and safety of step-down prescribing.