Purpose of investigation: to reveal the combined influence of hypo (Zn, Fe) and hyper (Cd, Pb) microelementosis on functional status of the cardiovascular, endocrine systems and anxiety level of adolescents (13 years of age) living in a chemically contaminated area in Stavropol region. The level of microelements (Cd, Pb, Fe, Zn, Cu) in hair and nails was determined by atomic absorption spectrophotometry method, cortisol in saliva - by ELISA method. The state of the cardiovascular system and its regulatory mechanisms was determined by indicators of variational pulsometry. To assess anxiety level of adolescents test method "Anxiety scale" was used. The analysis of microelement composition of hair and nails in adolescents, living in conditions of chemical environmental pollution with Cd and Pb subliminal doses, revealed the presence of hypo- (Zn, Fe) and hyper- (Cd, Pb) microelementosis. At the same time, increased levels of cortisol in saliva more evident in boys, increased heart rate and mode amplitude, peassure of the central mechanisms of the heart function regulation have been discovered. Change of anxiety level was stated. It has been proved that the determination of the microelement composition of hair and nails can serve as a marker of environmental contamination and complex negative changes, including the imbalance of microelements in hair and nails, functional changes in leading adaptive systems - the hypothalamic-pituitary-adrenocortical axis, cardio-vascular, changes of anxiety level can be used as a marker of dysaptation and predictor of psychosomatic problems.

102 schoolchildren of the 9-11 th classes of secondary school No. 2 of Stavropol, without genetic pathology, were examined. The functional state of the central nervous system was determined by the method of computer chronoreflexometry; using psychological tests, we determined the level of personality (PA) and situational (SA) anxiety, as well as (and) the level of aggressiveness. It was established that in the 9-11th classes, girls and young women have a higher level of PA and SA than boys and young men (p <0.05-0.01). During the training the girls' and boys' the level of PA remains relatively constant, however, the variability of PA of 17 years-old young women is higher than of the young men. The level of SA of the girls tends to increase throughout the entire period of study in high school, while for boys it rises only the 10 th class, and decreases by the beginning of the 11 th class. For the indicators of aggression, gender differences begin to appear in the 10 th class: aggressiveness index and indirect aggression in the boys' significantly higher than the girls' are. In the 11 th class, young men significantly increase in comparison with girls an indicator of hostility, verbal aggression and offence (p <0.05).

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