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Computer-assist drug design uses computational chemistry to discover enhance or study drugs and related biologically active molecules. Two distinct approaches are possible in the area of computer-aided drug design. If the molecular structure of the target macromolecule is known the methods are obvious and direct and have achieved a high level of sophistication. That area may be extended by using computational techniques to predict protein structure like Cancer-Causing H-Ras p21 Mutant Protein and to stimulate drugreceptor interactions. CADD methods are heavily dependent on bioinformatics tools, applications and databases. As such, there is considerable overlap in CADD research and bioinformatics. When the only lead is a set of known active compounds or knowledge of a biochemical transformation which is to be interrupted, then the path is less direct. Currently favored tactics include the use of molecular similarity methods and the employment of neural networks. Recent advances include the prediction of the relative potency of different chiral forms of drugs.

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The former US President George Bush articulated the idea o f a "new world order" on September 1 1 , 1990 in a speech for the build-up to the Gulf War. Explaining a new world order he said, "A New World Order, a new era, free from the threat of terror, stronger in the pursuit of justice, and more secure in the quest for peace, an era in which the nations of the world can prosper and live in harmony."' It is an irony of fate that September 11 , 2001 proved to be the blackest day not only for the American nation but for the entire global community. It witnessed unprecedented terrorist attacks on the twin World Trade Center Towers in New York, and the Pentagon in Washington, killing 5000 and 189 people respectively.2 The entire world watched it on their television screens with utter disbelief and horror. The world had just seen how terrible the consequences can be when terrorists have the hatred to murder innocent civilians, the resources to co-ordinate and conduct systematic operations, and the fanaticism to sacrifice their own lives. There was widespread reaction against the incident in every nook and comer ofthe world. Romano Prodi, President, European Commission, reacted, "The barbaric attack was directed against the free world and our common values. It is a watershed event and life will never be quite the same again. European institutions and governments will work closely together with our American Eends and partners in the defence of fieed~rn."~ Vladimir Putin, the Russian President, expressed his anguish by saying, "There is no doubt that such inhuman actions cannot be left unpunished. The whole international community mustrally inthe fight against terr~rism.~'~ TheGermanchancellor, Gerhard Schroeder, said, "This is not only an attack on the United States but an attack on the civilized ~o r l d . "~; Abdelouahed Belkeziz, Secretary-General, Organisation of the Islamic Conference, said, "We denounce and condemn those criminal and brutal acts that run counter to all covenants, humanitarian values and divine religions, foremost among which