ABSTRACT. We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and 5016 controls in 12 casecontrol studies were included in this meta-analysis. Variant A allele carriers showed a 48% increased risk of CAD compared with homozygote A allele [odds ratio (OR) = 1.48, 95% confidence interval (CI) = 1.18-1.87 for AA + AG vs GG]. In subgroup analysis by gender, significantly elevated risks were found in the mixed group (OR = 1.78, 95%CI = 1.42-2.22) but not in males (OR = 1.12, 95%CI = 0.79-1.57). In subgroup analysis by disease type, significant elevated risks were associated with A allele carriers in myocardial infarction [OR = 1.69, 95%CI = (1.05-2.71)], in coronary (2015) heart disease (OR = 1.36, 95%CI = 1.00-1.86), but not in coronary heart disease plus diabetes mellitus subjects (OR = 1.57, 95%CI = 0.58-4.29). Moreover, those with the GG genotype consumed significantly more alcohol than those with the AA/AG genotypes (standard mean deviation: 6.32 g, 95%CI = 2.09-10.55, P = 0.000). ALDH2 polymorphisms may be risk factors for CAD. Moreover, CAD patients with ALDH2 genotypes AG and AA consumed significantly less alcohol than those with GG. To further evaluate gene-gene and gene-environment interactions between ALDH2 polymorphisms and the risk of CAD, more studies with larger groups of patients are required.
Prolactin (PRL), a polypeptide hormone synthesized and secreted by the animal's anterior pituitary gland, plays an important role in the regulation of mammalian lactation and avian reproduction. Considering the significant association between single nucleotide polymorphisms (SNPs) in the 5'-flanking region of PRL and reproduction traits in the chicken, the objective of this study was to screen for SNP in the 5'-proximal region of PRL in geese and to evaluate the association between SNP and reproduction traits in geese. Chinese Wan-xi White geese (n = 200) and European Rhine geese (n = 80) were used for phenotyping. SNP was screened by comparing sequences of PCR products, and the single-stranded conformational polymorphism (SSCP) protocol was adopted for genotyping. Three SNPs (A-401G, G-268A and T-266A) in the 5'-proximal region of goose PRL were identified in both breeds. Statistical analysis suggested that the genotype AA characterized by A-401, G-268 and T-266 had a positive genetic effect on egg production. Therefore, these polymorphisms have the potential to be utilized in molecular breeding for egg production in geese.
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