In managing HIV/AIDS with highly active antiretroviral agents, the historical therapeutic aim remains to maintain the plasma concentrations at a level above the half maximal inhibitory concentration (IC50) required for 50% inhibition in viral replication. Concentration dependent toxicity is often observed in patients with elevated drug exposure and high peak plasma levels in lieu of accurately calculated drug dosages. Similarly low plasma concentrations are frequently witnessed in individuals receiving adequate dosage regimens. Pharmacogenetic variations in drug metabolizing enzymes may contribute to this phenomenon. Over the last decade, knowledge about the role of pharmacogenetics in the treatment and prediction of ARV plasma levels have increased significantly. However, the extent of these genetic variations remain largely unknown in the South African population, which has sparked a renewed enthusiasm for local pharmacogenetic studies.

In managing HIV/AIDS with highly active antiretroviral agents, the historical therapeutic aim remains to maintain the plasma concentrations at a level above the half maximal inhibitory concentration (IC50) required for 50% inhibition in viral replication. Concentration dependent toxicity is often observed in patients with elevated drug exposure and high peak plasma levels in lieu of accurately calculated drug dosages. Similarly low plasma concentrations are frequently witnessed in individuals receiving adequate dosage regimens. Pharmacogenetic variations in drug metabolizing enzymes may contribute to this phenomenon. Over the last decade, knowledge about the role of pharmacogenetics in the treatment and prediction of ARV plasma levels have increased significantly. However, the extent of these genetic variations remain largely unknown in the South African population, which has sparked a renewed enthusiasm for local pharmacogenetic studies.

Abstract:The study investigated the extent of information the nurses have about Occupational Therapy (OT) and its place within a health Multidisciplinary Team (MDT). It took place in the paediatric ward of the Dr George Mukhari Academic Hospital in Gauteng Department of Health. It was stimulated by the adverse attitude of the nurses to the OT staff and/or students from Sefako Makgatho Health Sciences University (SMU) for prescribed OT activities in that ward. The purpose of the study was to demonstrate that if nurses in a MDT setting did not understand OT purpose, then this may cause lack of their appreciation of OT activities and of occupational therapists. Forty-three nurses participated in the study. Most of them did not know much about OT and seemed to have different impressions about the OT profession. The study recommended that the nurses should be informed about other practitioners in the MDT of their workplace, how each one works and the scope of the nurses' work.