The quarrying of marble and its processing to produce building materials often generates a negative impact on the environment. In the Apuan Alps marble district, a renowned quarrying area in Italy since ancient times, the aquatic pollution of water bodies, caused by the presence of marble waste in the form of powder or sludge, represents a significant and current environmental problem. Depending on the different national and international regulations on waste management, the marble waste can be classified as a special non-hazardous industrial waste. If marble waste has been managed according to environmental international and national laws, it can be reused as a by-product. For this, the present work aims to evaluate the reuse of marble waste as a material in replacement for cement for producing mortars. Subsequently, the mechanical and physical tests were carried out to evaluate the specific properties of the obtained materials during and after the curing time. The results showed that replacement of cement into mortars by marble waste always causes a decrease of mechanical properties, with still acceptable values for many applications up to a substitution of less than 25%. From the collected data, the use of marble waste in the production of cement mortars represents an adequate and sustainable destination of this by-product.