Introduction and hypothesis The aim of this study was to evaluate a link between mesh infection and shrinkage. Methods Twenty-eight Wistar rats were implanted with synthetic meshes that were either non-absorbable (polypropylene (PP), n=14) or absorbable (poly (D,L-lactic acid) (PLA94), n=14). A validated animal incisionnal abdominal hernia model of mesh infection was used. Fourteen meshes (n=7 PLA94 and n=7 PP meshes) were infected intraoperatively with 10e6 CFU Escherichia coli, and compared with 14 non-infected meshes (n=7 PLA94 and n=7 PP meshes) (control groups). Explantations were performed on day 30. Shrinkage was evaluated by a reproducible numerical analysis of mesh area. Infection and histological study were evaluated on day 30.Results Non-infected meshes were less shrunk than infected meshes for both non-absorbable (5.0±1.7% versus 21.6±6.1%, p<0.05) and absorbable meshes (2.4±0.9% versus 11.0±2.5%, p<0.05). Conclusion This study highlights a link between infection and shrinkage in the model used.

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La chirurgie vaginale prothétique est-elle une stratégie valide chez une patiente présentant une cystocèle récidivée après promontofixation ? Is vaginal surgery using mesh a valid option in women with recurrent anterior vaginal wall prolapse after abdominal sacrocolpopexy? L. Mamy · V. Letouzey · P. Merviel · J. Gondry · P. Mares · P. Costa · R. de Tayrac Reçu le 2 avril 2010 ; accepté le 6 avril 2010 Conclusion: Vaginal surgery using mesh is a valid option in women with recurrent anterior vaginal wall prolapse after abdominal sacrocolpopexy.