A correct soil moisture estimation is a fundamental prerequisite for many applications: agriculture, meteorological forecast, flood and drought prediction, and, in general, water accounting and management. Traditional methods typically provide point-like measurements, but suffer from soil heterogeneity, which can produce significant misinterpretation of the hydrological scenarios. In the last decade, cosmic-ray neutron sensing (CRNS) has emerged as a promising approach for the detection of soil moisture content. CRNS can average soil moisture over a large volume (up to tens of hectares) of terrain with only one probe, thus overcoming limitations arising from the heterogeneity of the soil. The present paper introduces the development of a new CRNS instrument designed for agricultural applications and based on an innovative neutron detector. The new instrument was applied and tested in two experimental fields located in Potsdam (DE, Germany) and Lagosanto (IT, Italy). The results highlight how the new detector could be a valid alternative and robust solution for the application of the CRNS technique for soil moisture measurements in agriculture.

Copper radioisotopes are generally employed for cancer imaging and therapy when firmly coordinated via a chelating agent coupled to a tumor-seeking vector. However, the biologically triggered Cu2+-Cu+ redox switching may constrain the in vivo integrity of the resulting complex, leading to demetallation processes. This unsought pathway is expected to be hindered by chelators bearing N, O, and S donors which appropriately complements the borderline-hard and soft nature of Cu2+ and Cu+. In this work, the labelling performances of a series of S-rich polyazamacrocyclic chelators with [64Cu]Cu2+ and the stability of the [64Cu]Cu-complexes thereof were evaluated. Among the chelators considered, the best results were obtained with 1,7-bis [2-(methylsulfanyl)ethyl]-4,10,diacetic acid-1,4,7,10-tetraazacyclododecane (DO2A2S). DO2A2S was labelled at high molar activities in mild reaction conditions, and its [64Cu]Cu2+ complex showed excellent integrity in human serum over 24 h. Biodistribution studies in BALB/c nude mice performed with [64Cu][Cu(DO2A2S)] revealed a behavior similar to other [64Cu]Cu-labelled cyclen derivatives characterized by high liver and kidney uptake, which could either be ascribed to transchelation phenomena or metabolic processing of the intact complex.

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