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BACKGROUND. The leading role in the development of vulvovaginitis in girls of pre-school age belongs to the extragenital diseases, including recurrent urinary tract infections. The study of medical and social factors that affect the development of reproductive health disorders is of urgent importance. THE AIM: to study the medical and social risk factors for recurrent vul­vovaginitis in preschool girls suffering from urinary tract infections. PATIENTS AND METHODS. A prospective controlled study was conducted in 107 girls aged 3-6 years, including group 1 (n=45) - patients with vulvovaginitis against the background of recurrent uncomplicated urinary tract infection; group 2 (n=32) - patientswith an isolated form of vulvovaginitis; group 3(n=30) - girls of health groups 1 and 2. The main parameters of social and biological anamnesis are analyzed. Statistical analysis was performed using the program "SPSS Statistics V. 17.0" ("SPSS Inc. IBM Company", USA). RESULTS. Patients with a combined form of vulvovaginitis, in comparison with patients with isolated vulvovaginitis, more often lived in rural areas, were from large families, belonged to the group of preschool children who do not attend preschool educational institutions, in their families, the monetary income was lower than the subsistence minimum (p<0.001). The lowest level of hygiene was observed in pa­tientswith isolated forms of vulvovaginitis. In patientswith combined forms of vulvovaginitis, in comparison with patientswith isolated vulvovaginitis, gestational complications were significantly higher: 22.2% had gestational pyelonephritis, 13.6% had a premature birth, and 22.2% had a cesarean section (p <0.05). CONCLUSION. Patients with vulvovaginitis and recurrent UTI have a burdened social and biological history. In dispensary management, an interdisciplinary approach is required, taking into account the identified medical and social risk factors.

Аннотация. Статья посвящена проблеме патологии почек у взрослых и детей при нефропатии, ассоциированной с антифосфолипидным синдромом (АФС). Нефропатия является частью клинической картины АФС. В основе нефропатии при АФС лежит тромботическая микроангиопатия (ТМА), представляющая собой особый тип поражения сосудов микроциркуляторного русла различных органов. Прогностически неблагоприятным самостоятельным заболеванием является АФС-нефропатия (АФСН). Клиническая картина АФС-ассоциированной нефропатии отличается многообразием тяжести клинических симптомов. Описаны основные симптомы АФС-нефропатии, формирующие клинические варианты АФСН. Показаны различия в течении АФС-ассоциированной нефропатии среди мужчин, женщин и детей. Ключевые слова: антифосфолипидный синдром (АФС), сосудистые нарушения, почки.