An ethnobotanical survey of medicinal plants used in curing some diseases in infants in Abeokuta South Local Government Area of Ogun State, Nigeria was carried out between February and June, 2012. Ethnobotanical data were collected by oral interview with the aid of a semi-structured questionnaire administered to fifty (50) respondents made up of traditional medical practitioners (TMPs), herbalists and herb sellers. From the survey, a total of 63 plant species belonging to 33 families were found to be useful in the treatment of cold, malaria, fontanel, diarrhoea, typhoid, chicken pox, measles and small pox. Recipes used in the treatment of these ailments were documented. Herbal remedies were either prepared from dry or freshly collected plants while the traditional solvents of choice includes water, pure honey, lime and aqueous extracts from fermented maize. The methods of preparation were decoction and infusion while method of administration ranges from 1 drop to 1 teaspoonful daily. Survey revealed that leaves form the major part of plant for herbal preparations. Residents in the study area find the traditional medicine cheaper as compared to orthodox medicines. It is therefore implicated that efforts should be made on how to improve on documentation, conservation and standardization of the medicinal plants in Nigeria. Also, attention of the scientists and health officials should be drawn to the importance and various uses of the medicinal plants and they should intensify on the research to reveal other concealed values.