Se hace el estudio inmunológico de 90 proteínas de MM y MW clasificándolas por clases, subclases, tipos y marcadores genéticos. Se observa una proporción de 2.2% de MM IgD; 2.2% de MW; 24% de MM de la clase IgA y 71% de la clase IgG. Al ana´lizar las subclases de esta última se observa la siguiente proporción de IgG1 77%, IgG2 12%, IgG3 6% e IgG4 3%. Los bajos niveles de estas últimas subclases se relacionan con el marcador genético "Gm" más frecuente postulado para la población colombiana que es Gm (4a), Gm (n-), Gm (g) y Gm(z,a)

The purpose of this investigation was to demonstrate platelet aggregation defects in patients infested with Plasmodium, giant and normal platelets counts.Laboratory studies were performed by using a “Payton Aggregometer”. ADP, Collagen, Epinephrine and Ristocetin as commercial reagents. Coagulation tests were done by regular methods. Thirty out of 31 patients were found to have marked defects in secondary aggregation wave with ADP. Aggregation with Collagen was constantly abnormal. Fifteen patients showed primary and secondary aggregation abnormality with ADP, Adrenaline and Collagen. Aggregation with Ristocetin was always normal. Aggregation defects were not drug induced since the patients were taking no medicines at least five days prior to studies.Studies done in volunteers taking antimalarics, Dipirone, Acetaminophen showed no interference with aggregation. Aggregation abnormalities were mostly found in patients infested with chronic Falciparum malaria. Most of the patients did not have bleeding manifestations but had multiple organ involvement. We think this platelet defect is a manifestation of some defense mechanism to prevent massive thrombosis frequently found in Falciparum Malaria.