It were examined 70 young women with PCOS. It was established, that these patients have lower levels of folic acid than healthy women, 47 % — reduction below reference values of norms, 52.8 % — hyperhomocysteinemia. Folic acid treatment at a dose of 5 mg/day helped to normalize its levels for 12 week therapy at that at women with normal body weight normalization was faster. The concentration of homocysteine during treatment as high as indicators of healthy women at patients with normal weight for 12 weeks of therapy, and at patients with obesity — for 24 weeks. Determination in blood levels of folate and homocysteine should be included a comprehensive examination of this category of patients, particularly at the stage pregravid period.

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The aim of the work was to study the relationship between levels of vitamin D, obesity and lipid profilein patients with polycystic ovary syndrome (PCOS).Materials and methods. The study involved 120 women: 60 patients with PCOS and 60 healthy women.All examined were divided into groups depending on body mass index (BMI): patients with PCOS — 30 withBMI ≤ 25 kg/m2and 30 with BMI ≥ 25 kg/m2; healthy women — 30 with BMI ≤ 25 kg/m2and 30 withBMI ≥ 25 kg/m2. Results. Patients with a BMI of ≥ 25 kg/m2had a lower average level of vitamin D (P < 0,001) than patientswith a BMI of ≤ 25 kg/m2; among of them there was a higher percentage of women with a pronounceddeficiency (23.3% versus 13.3%) and deficiency (60% versus 50%) of vitamin D; nobody had not adequate levelsof vitamin D. It was established a negative correlation between the level of vitamin D and BMI (r = – 0.275;P < 0.05), waist circumference (r = – 0.604; P < 0.001), the coefficient of waist circumference/ hips circumference(r = – 0.512; P < 0.001). Abdominal type of adipose tissue distribution, which was observed among patients withboth overweight and normal weight, may be one of the factors contributing to dysregulation of metabolism of vitaminD in conditions of PCOS.Women with PCOS had lipid metabolism disorders with increased atherogenic and decreased levels of antiatherogeniclipid fractions wich was intensif with increasing body weight. It was established a negative correlationbetween the level of vitamin D and triglycerides (r = – 0.437; P < 0.001), and positive association with highdensity lipoprotein cholesterol (r = 0.492; P < 0.001).In healthy women, only a negative correlation between the concentration of vitamin D and BMI (r = – 0.562;P < 0.001) was establish and there was no association with other anthropometric indicators and indicators of theblood lipid spectrum.Conclusion. Patients with PCOS have a higher prevalence and severity of deficiency of vitamin D.Disruption of regulation of vitamin D metabolism may be a consequence of existing obesity, and a decrease invitamin D levels is an additional factor that increase the dyslipidemia that exists in PCOS.

It was examined 55 patients with PCOS that were divided into groups depending on the functional state of the thyroid gland: 21 women with autoimmune thyroiditis in euthyroid stage, 14 women with autoimmune thyroiditis which was combined with subclinical hypothyroidism, 20 — without a thyroid dysfunction. It was found that the euthyroid dysfunction aggravates the typical for the classic phenotype of PCOS the hormonal disorders — increase the total testosterone, the free androgen index and decrease the sex-steroid-binding globu­lin. The absence of a correlation between TTG and LH, LG / FSH indicates different mechanisms formation of PCOS and thyroid pathology.

Influence of prolactin on condition of a carbohydrate metabolism at patients with polycystic ovary syndrome is studied. It is established, that hyperprolactinemia increase aberrations at carbohydrate metabolism in the form of higher glycemic reaction to loading of glucose, increases frequency development of aberrations of tolerance to glucose, insulin resistance and hyperinsulinemia.