SummaryBasal t-PA antigen concentration, PAI-I activity and tibrinolytic capacity was studied in plasma from 20 healthy teenager girls (age 15.9 ± 1.3 years) and two groups of older healthy volunteers, consisting of L7 women (age 32 ± 8 years, group 1) and 35 men (age 34 ± 8 years, group 2). Basal t-PA antigen concentrations in plasma were found to be highly age-dependent with higher values with increasing age. The teenager girls had significantly lower values compared with the two groups of elderly volunteers. PAI-I levels were significantly higher in plasma from the teenager girls and the fibrinolytic capacity after 15 min of venous occlusion was significantly lower.In this study we also determined the effect of low-dose oral contraceptives (OC) on coagulation and fibrinolysis in the teenager group. Each teenager served as her own control with samples drawn before and on OC after 4 months of use. The coagulation parameters, factor VIII activity, AT III, protein C and platelet counts were all within reference values before and on OC. The fibrinolytic activity in plasma after venous occlusion (15 min) increased significantly when the teenagers had used OC for 4 months. This phenomenon was explained by significantly decreased PAI levels and also by significantly increased t-PA antigen release from the vessel wall after venous occlusion.

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The purpose of this study was to evaluate the cost of the menstrual cycle for young Swedish women aged 14-20 years. The young women were randomly selected and interviewed by a trained female psychologist; a total of 68 young women completed the interviews. Twenty of the girls used oral contraceptives, while 48 had natural periods. The oral contraceptive users had a lighter menstrual flow and shorter periods (1 day less) than the girls with natural menstruation. The oral contraceptive users experienced less menstrual pain, used fewer painkillers and did not stay at home during their periods as often as the girls with natural periods. The cost of sanitary protection products was about US$1 per month less for the oral contraceptive users. Girls taking oral contraceptives also avoided stained underwear and soiled bedlinen significantly more often than the non-oral contraceptive users. The study design did not allow for cost estimates on soiled underwear, bedlinen or lost work- or schooldays. The results of the study indicate that expenditures related to the menstrual cycle are considerable for young Swedish women.