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In this paper the authors discuss a method using 1-nm particulate radon decay products as an experimental tool in the study of local lung deposition and dosimetry for nanoaerosols. The study of aerosol exposure and dosimetry measurements, and related quantitative assessment of health effects, are important to the understanding of the consequences of air pollution, and are discussed widely in the scientific literature. During the last 10 years the need to correlate aerosol exposure and biological effects has become especially important due to rapid development of a new, revolutionary industry--nanotechnology. Quantitative assessment of aerosol particle behavior in air, in lung deposition, and dosimetry in different parts of the lung, particularly for nanoaerosols, remains poor despite several decades of study. Direct nanoparticle dose measurements on humans are still needed in order to validate the hollow cast, animal studies, and lung deposition modeling. The issue of the safe use of radon progeny in such measurements is discussed. One of the properties of radon progeny is that they consist partly of 1-nm radioactive particles called unattached activity; having extremely small size and high diffusion coefficients, these particles can be potentially useful as radioactive tracers in the study of nanometer-sized aerosols.

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Citation: Ruzer LS (2011) Exposure and Dose: Health Effect Studies Associated with Nanometer Aerosols. J Nanomedic Nanotechnol 2:120. doi:10.4172/2157-7439.1000120Copyright: © 2011 Ruzer LS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Exposure and Dose: Health Effect Studies Associated with Nanometer Aerosols Lev S. RuzerLawrence Berkeley National Laboratory, USA AbstractThe nanotechnology industry is rapidly growing with promises of substantial benefits that will have significant global economic and scientific impacts applicable to a whole host of areas from engineering and electronics to environmental remediation and medical healthcare. However, at present there is growing concern over the safety of nanomaterials with respect to occupational, consumer and environmental exposures and associated health effect. Particularly, information on nanomaterial exposure, dosimetry, risk assessment and health effect is negligible. In this paper we discussed the problems of the Exposure and Dose in the studies of the health effect related to nanoaerosols. As a general plan for the assessment of the Dose -the main cause of the effect -Nanoparticles Dosimetric Road Map is presented. The new ideas for measurement of the surface area of nanoparticle, local nanoparticle lung deposition, and nanoparticles respirators true effectiveness are proposed. Citation: Ruzer LS (2011) Exposure and Dose: Health Effect Studies Associated with Nanometer Aerosols.

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