Pancreatic blood flow was studied in dogs by measuring local hydrogen gas clearance. External pancreatic secretion was collected by cannulation for volume measurements. In 16 expts. (15 dogs), recordings were obtained in pentobarbital (Nembutal) anesthesia. The mean value of 115 observations was 42.8 (S.E. 4.3) ml/min. 100 g pancreas. In 3 dogs, measurements were made in the awake, fasted state by means of chronically implanted electrodes, which proved effective for about two weeks. Mean of 33 observations was 76 ml/min. 100 g. The correlation between pancreatic blood flow and external secretion was studied by means of secretin (Boots, Jorpes) and pancreozymin (Boots). A variable response occurred, which proved to be time‐dependent and not correlated to the state of secretion or stimulation. An acute rise in blood flow was seen when hormone administration was started or increased. This effect was immediate but transient; blood flow returned to pre‐stimulatory level after 20 min, whereas the external secretion continued unchanged. No effect was noticed on gastric hydrogen clearance recorded in 4 of the dogs, indicating an organ specificity of the hormonal influence.

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Two series of experiments were carried out in three healthy volunteers. In one series increasing doses of cimetidine were tested on a constant background stimulation with 0.15 microgram-kg-1h-1 of pentagastrin. In the other series of experiments increasing doses of pentagastrin were given either alone or in combination with a fixed dose of cimetidine (1.2 mg-kg-1h-1). Pentagastrin and cimetidine were given as continuous intravenous infusions, the various doses tested on separate days. The inhibition of acid output in response to pentagastrin stimulation increased almost linearly with the log dose of cimetidine. Fifty per cent inhibition of the response to 0.15 microgram-kg-1h-1 of pentagastrin was achieved by about 0.6 mg-kg-1h-1 of cimetidine. 2.4 mg-kg-1h-1 of cimetidine gave on average 90% inhibition. The inhibition caused by cimetidine decreased to a minimum of 57% and could not be overcome by increasing the doses of pentagastrin. The results suggest a mixture of competitive and noncompetitive interaction. The effect of cimetidine on pepsin secretion was less regular. Generally, pepsin output was less inhibited than acid output.

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