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FIG. 1. Transition from the resting (digffolic) to the active (systolic) sate of cardiac myofibrila. Ashiftinthe orientation of the cross-bridges is associated with a longitudinal movement of the thin filament

The two-phase flow correlations developed by Murdock, James, Marriott, and Smith and Leang are evaluated for the case of flow through sharp edge measuring orifices which physically meet ASME standards for flow measurement. The evaluation is based on two sets of consistent orifice flow data. The first data base consists of 34 test points for the flow of steam-water mixtures. The second data base consists of 81 data points for the flow of air-water, natural gas-water, natural gas-salt water, and natural gas-distillate mixtures. The root mean square fractional deviation of each correlation is used to determine its predictive reliability. Computed root mean square fraction deviations for steam-water flows are: James, ±0.081; Marriott, ±0.114; Murdock, ±0.141; Smith and Leang, ±0.218. For the case of gas-liquid flows, the values are: Murdock, ±0.074; James, ±0.178; Smith and Leang, ±0.183; Marriott, ±0.458.

Aspirin can be an effective antipyretic, analgesic and anti-inflammatory agent, but unfortunately, its use in the elderly is often excessive [43]. In a survey by Gillies and Skyring, the overall prevalence of daily aspirin intake was greater in middle-age and older-age groups than for those of less than 40 years of age [16]. The elderly are susceptible to the advertising of non-prescription drugs and aspirin is frequently self-prescribed [8,31]. Age-related physiological changes modify the response to aspirin in the elderly. A higher incidence of drug reactions and interactions has been evidenced in this age group. The cases cited throughout this report substantiate the need for caution on the part of the geriatric patient and the physician in regard to aspirin therapy for the elderly.

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