Background: Liver cancer is the most common cancer in Vietnam. Along with the current trend of developing techniques in the treatment of hepatobiliary diseases, many patients can approach more radical treatments. In recent times, one of the advanced techniques in the field of liver cancer treatment is Associating Liver Partition and Portal vein Ligation for Staged hepatectomy (ALPPS) procedure -a radical treatment for patients with relatively late stage liver cancer and insufficient future liver remnant that portal vein embolization cannot be performed to enlarge the remnant liver. Methods: A prospective Cohort study was performed from May 2018 at University Mecical Center at Ho Chi Minh city. The inclusion criteria are patients diagnosed with liver cancer who are indicated for right hepatectomy or right trisectionectomy with insufficient future liver remnant and unable to perform percutaneous portal vein embolization. Results: From May 2018 to the end of December 2022, 37 cases that met the inclusion criteria were enrolled in the study. However, there were 8 cases that met the exclusion criteria, so there were 29 patients left in the research. The average age was 51.34 ± 14.27, male: female ratio was 6.25:1. Hepatocellular carcinoma stage BCLC C accounted for 44.8%. The rate of laparoscopic surgery in stages 1 and 2 was 86.2% and 20.7%, respectively. The median interval between 2 stages of surgery was 32 days (7 to 110 days). The median enlarged liver volume was 168.39 mL (69.85-445.9 mL), the median hypertrophy rate was 59.08% (20.9-243.4%). The rate of complications after stage 1 and 2 were 10.3% and 27.6%, respectively, and there was no perioperative mortality. The mean disease -free survival and overall survival were 26.31 months (95% CI: 16.09-36.52 months) and 39.08 months (95% CI: 29.92-48.24 months), respectively. Conclusions: ALPPS procedure is an innovation for the treatment of liver cancer that still ensures safety and effectiveness. However, due to the new technique and small sample size, further development and research is needed to evaluate the pros and cons of this promising method.

post-operative pancreatic fistulae or delayed gastric emptying. There were no differences in median OS (32 vs 48 months, p = 0.86), median RFS(16 vs 36 months, p = 0.17), or patterns of recurrence (local, regional, or distant) between MD and PD tumors. Conclusions: Poorly differentiated PDAC is characterized by more frequent or persistent perineural invasion relative to moderately differentiated tumors following preoperative therapy. However, tumor differentiation has no impact on postoperative patterns of local or distant tumor recurrence or the incidence or severity of post-operative complications.

Background: Liver transplantation is one of the most effective treatments of end-stage benign liver diseases and early hepatocellular carcinoma within Milan criteria. An increasing pool of donor organs plays a major role in the treatment of more patients on the liver transplant waiting list. Currently, liver transplantation has been performed at our center with early satisfactory results. Methods: A prospective cohort study was performed from June 2018 at University Medical Center at Ho Chi Minh City. Selective patients have been satisfied the criteria for liver transplantation. Results: Overall survival rate after liver transplantation at 6 months, 12 months, 24 months, and 36 months is 82.4%, 47.1%, 23.5%, and 5.9%, respectively. The recurrent rate has been not recorded. Two cases died due to severe sepsis. Surgical complications have included hepatic arterial thrombosis (5.9%), portal stenosis (11.8%), middle hepatic venous thrombosis (23.6%), biliary leakage (5.9%), small intestinal perforation (5.9%), and splenic abscess after splenic arterial ligation (5.9%). In addition, internal matters have been recorded, such as graft rejection (11.8%), pneumonitis (11.8%), and renal failure (5.9%). All cases of graft rejection were responded with a high dose of corticosteroids. All cases considered, there were 16 cases of living donor liver transplantation and two cases of deceased donor liver transplantation. One of 16 cases of the living donor was suffered biliary leakage after hepatectomy and treated by endoscopic retrograde cholangiopancreatography with the stent. The mortality rate has not been recorded. Conclusions: Results of liver transplantation show that satisfactory outcomes of overall survival, complications, morbidity, and mortality. In addition, living donor liver transplant procedure has brought in the safety of living donors and recipients based on the improving techniques of hepatectomy and more ability in the treatment of patients on the waiting list.