Despite the fact that over the last few years downward trend in the incidence of acute forms of viral hepatitis B continues, the incidence of chronic hepatitis B (CHV) has increased by 2.5 times since 1998. To date, there are a sufficient number of antiviral drugs, but their use is associated with a set of contraindications, as well as the development of resistance. In this study there was performed an evaluation of a new national drug " Stimforte " in patients with chronic viral hepatitis B (CVHB - DNA positive, HBsAg - positive) at the stage of exacerbation. In the study there were included 28 patients with chronic hepatitis B (HBsAg positive), at different grades of activity, at a stage of viral replication. The diagnosis of chronic hepatitis B was made on the presence in a history acute viral hepatitis for more than 1 year, complaints, hepatolienal, astenovegetative, cytolytic syndromes, the presence of DNA-HBV, anti-HBcore IgM, HBsAg. After 1 course of treatment with " Stimforte " the well-being of patients has improved: in 30% of patients asthenic- vegetative syndrome had disappeared, weakness, fatigue and dyspeptic symptoms were decreased. The use of "Stimforte" in chronic hepatitis B with positive HBsAg at the stage of exacerbation contributed to a more rapid normalization of such indices as ALT, AST, compared with those in the control group. Long-term biochemical and virological remission was achieved in 40 %. It is established that during the treatment the viral load was reduced progressively until the undetectable or low level of HBV DNA and anti-HBc IgM disappeared. In only one case an allergic reaction was observed, which has not hindered to perform a complete course of treatment. No other side effects were detected. The inclusion of the drug "Stimforte" in the complex therapy of patients with exacerbation of chronic hepatitis B reduces the time of recovery of immune status and functional activity of IFN system and contributes to reduction of the viral load or elimination of the virus.

Gamalei Str., Moscow, Russia, 123098; 4Closed 4Joint-Stock Company “SKY LTD”, 113/1, Leninsky avenue, Moscow, Russian Federation, 117108 Hepatitis B is a serious problem for global health. The incidence of acute hepatitis B in the Russian Federation in recent years was 2.2 per 100 000 people. In 5% of cases the infection can acquire chronic course, leading to the development of cirrhosis and hepatocellular carcinoma. Recently, there is increased interest in drugs of plant and animal origin which have immunomodulatory and antiviral activity. "Stimforte" is one out of such drugs. The aim of this work was to determine the as clinical and immunologic as virologic efficacy of the injectable form of the drug. The study included 30 patients and 22 subjects from the control group. Evaluation of treatment efficacy was performed on the results of clinical and laboratory examination and was determined in the terms of reverse development of acute viral hepatitis, dynamics and rate of downword in activity of biochemical parameters (ALT, AST, alkaline phosphatase), elimination of markers of acute hepatitis from the blood, the frequency of formation of chronic hepatitis. The investigation of immune and interferon status was performed. At the same time the possible occurrences of adverse reactions were taken into account. At the end of the study the use of "Stimforte " was shown to have a positive effect on the regression of clinical symptoms of the disease, by reducing their duration by 2-8 days, contributed to a more rapid normalization of indices of cytolysis (ALT, AST). Drug "Stimforte" has immunomodulatory effect, stimulated antiviral immune response to acute HBV-infection. Within 6 months of following up patients no chronic cases were observed. The drug was well tolerated by all patients with no incidence of adverse reactions.