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3-Amino-4-(phenyl or p-methoxyphenyl)- 6-pyridin-3-ylthieno[2,3-b]-pyridine-2-carboxamide and 3-amino-4-(phenyl or p-methoxyphenyl)-6-pyridin-3-ylthieno [2,3-b]pyridine-2-carbonitrile were used as the starting materials aiming to obtain the newly synthesized pyridothieno-pyrimidines, pyridothienotriazines and pyridothienoxazines via their reactions with several reagents e.g. CS 2 , HCOOH, CH(OEt) 3, Ac 2 O and HNO 2 . These newly synthesized heterocyclic compounds were tested as anti-Alzheimer and anti COX-2 agents and their structures were elucidated by considering the data of IR, 1 H NMR, mass spectra and elemental analyses.

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