hospital information system and their demographics, comorbidities and HP status were recorded retrospective. Results 468 obese patients (male: female, 1:1.7) with mean age of 48.3 (SD ± 15) years and mean BMI of 44.43 kg/ m² were analyzed. The prevalence of HP was 35% (166/ 469). There was no significant association of HP infection and gender (P = 0.557). There was no difference between the mean ages of patients infected with HP (40.2 ± 12 years) compared to those who were not (42.46 ± 13.7 years) (P = 0.076). Similarly was the case with glycated haemoglobin (6.79 ± 1.9 in HP positive compared with 6.85 ± 1.7 in HP negative, P = 0.708). However, the mean BMI was significantly higher in HP positive patients (46.75 ± 10.3 kg/m²) compared to HP negative (43.1 ± 8.2 kg/m²) (P = 0.0001). There was a positive linear correlation with BMI and HP prevalence (P = 0.0007) (IDDF2021-ABS-0127 Table 1). Conclusions The prevalence of HP in our study was positively associated with BMI, rising with increasing BMI. This may have implications for obesity management. Further populationbased studies are needed to confirm.

84.5%, respectively. SIRS score 2 in grade E was significantly higher than in grade D (89.1% vs 59.0%, p < 0.01). (IDDF2021-ABS-0121 Table 3). Conclusions Alcohol was the most common etiology. Hypocalcemia and SIRS score 2 correlated significantly with the occurrence of more acute peripancreatic fluid collections.

SGLT2i showed the greatest reduction in BMI, being superior to sulfonylurea (MD: -1.67, CI: -3.09 to -0.25) and standard of care (MD: 3.45, CI: 1.24 to 5.66). SGLT2i showed the greatest reduction of LDL and TG and the greatest increase of HDL. Conclusions SGLT2i, GLP-1RA and PPARg agonists are viable choices for the management of NAFLD in diabetic patients. SGLT2i was found to be most efficacious for fibrosis and BMI reduction, GlP1-RA for steatosis reduction and PPARg agonists for lipid modulation and should be considered over sulfonylurea for second-line therapy.

84.5%, respectively. SIRS score 2 in grade E was significantly higher than in grade D (89.1% vs 59.0%, p < 0.01). (IDDF2021-ABS-0121 Table 3). Conclusions Alcohol was the most common etiology. Hypocalcemia and SIRS score 2 correlated significantly with the occurrence of more acute peripancreatic fluid collections.

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