Background: To date, no study has been performed on the relationship between depression and perimenopausal symptoms using the Path model in Iran. Objective: This study aims to assess the relationship between depression and menopause symptoms using the PATH model. Methods: A cross-sectional study was conducted for 4 months in 2019 and 332 menopausal women enrolled in 14 public health centers. Data collection instruments included questionnaires of demographic characteristics, anxiety instrument, Menopause Rating Scale, and the Beck Depression short Inventory (BDI-S). The hypothesized mediators were assessed using Structural Equation Modeling (SEM). The model included depression symptoms (dependent variable), anxiety (mediators), number of alive children (moderator), and menopausal symptoms (independent variable). Analyses were conducted by SPSS 16 and AMOS 20. Results: There was a significant positive correlation between menopause symptoms with total anxiety (Rs=0.52), state anxiety (Rs=0.47), trait anxiety (Rs=0.46), and depression (Rs=0.54). Depression had a significant positive correlation with total anxiety (Rs=0.64), trait anxiety (Rs=0.58), and state anxiety (Rs=0.59). Also, the total mediating effect of total anxiety and depression and the total moderating effect of the number of alive children were significant on menopause symptoms. Conclusion: According to the results of the present study, there is an association between depression and menopausal symptoms. Therefore, health providers should pay more attention to the psychological health of women during the period of perimenopausal. The predictor factors should be considered in both intervention and clinical assessment of menopause women.

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Aim: Depression in patients after hip fracture has adverse effects on patient outcomes. This study aimed to identify the prevalence of perioperative depression and the risk factors which predispose patients undergoing emergency hip surgery to perioperative depression. Methods:A cross-sectional study was conducted in hip fracture survivors in an orthogeriatric unit in Western Australia, from 2005 to 2008. Patients were categorized as depressed if Geriatric Depression Scale (GDS) score was five or above. Linear regression was used to analyze the association between age and GDS. Modifying effect of dementia was examined using likelihood ratio test.Results: Depression was present in 18.3% of 1127 patients within two weeks after hip fracture. Mean age was 81.2 years. Prevalence of perioperative depression was highest in the old-old (24.1%) and in patients with pre-existing dementia (64.8%). Advancing age, prefracture institutionalization, use of gait aids, poor physical status, and dementia were associated with higher GDS scores, but not gender or perioperative delirium. The association between increasing depressive symptoms and advancing age was significant in patients without dementia but not in patients with dementia. Conclusions:Depressive symptoms were common during perioperative care for emergency hip surgery. Depression was highly prevalent in patients with dementia after hip fracture regardless of their age. Pre-morbid patient factors may help to identify those patients at risk for depression and should be addressed to optimize rehabilitation participation and outcomes.

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