The main objective of cancer therapy is to prop up the death of cancer cells without any damage to surrounding healthy tissue. Our knowledge of molecular changes in cancer cells has enhanced the development of various therapeutic strategies to treat cancer cells. Now we are in an ideal position to utilize our knowledge of cancer cell biology in the designing of novel cancer therapies. This review is to highlight various specific and selective approaches (Chemotherapy, Radiotherapy, Surgery, Biological therapy) to understand its modality and current progress in cancer treatment.