Snakebite is a defense mechanism of snakes and can be a medical emergency. Snake venom contains a mixture of protein components that affect the functional activity of the target physiology. The structure of the poison in snake venom has different variations for different snake species. As for snakebite,  it can be life-threatening if it has neurotoxic, cytotoxic, or hemotoxic toxic effects.  The purpose of this study is to determine the relationship between snakebite incidence to osteomyelitis and cardiogenic shock.  The results of this study can be used as a source of information and an objective correlation reference regarding the relationship between snakebite and osteomyelitis and cardiogenic shock. This research is a Systematic Review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses method or commonly called PRISMA, this method is carried out systematically by following the correct research stages or protocols.  Antivenom neutralizes toxins in fixed quantities. Both children and adults are given the same amount of antivenom because snakes inject the same amount of poison into both adults and children. Antivenom can be effective as long as the poison is still active in the patient's body causing symptoms of systemic intoxication. It can last for several days or even weeks after the bite.  After a series of processes have been passed, based on the results of research in the Scopus-indexed journal on the systematic "The Relationship of Snakebite with Osteomyelitis and Cardiac shock in Pediatric and Adult Patients" a conclusion can be drawn, namely that the majority of journals discuss heart disorders and infections, necrosis of muscles and bones related to poisonous snake bites.

There is a suspected relationship between osteoporosis and gallstone formation in patients with cholelithiasis with neuroleptic malignant syndrome. However, the characteristics of osteoporosis that are related to this problem have not been discussed in previous studies. Knowing the Characteristics of Osteoporosis Patients with Gallstone Formation in Patients Suffering from Cholelithiasis With Malignant Neuroleptic Syndrome. This research is a Systematic Review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses method or commonly called PRISMA, this method is carried out systematically by following the correct research steps or protocols. Sources were taken from the Google Scholar website with journals published in 2005-2022 and then screening was carried out to obtain the results of 1,910 journal articles. Journal clustering was carried out and the number of Scopus indexed journals obtained was 4 journals Q1, 1 journal Q2, and 1 Q4 journal, so that 6 journals were extracted.

Diarrheal disease continues to be one of the major public health problems worldwide, with more than 1.5 million deaths each year and most of them in children under 5 years of age. The incidence of diarrheal diseases averages 2-3 episodes per child per year. Excessive use of antibiotics as antidiarrheals is associated with an increase in bacterial resistance to antibiotics, medical costs, and the incidence of side effects. In past research, it has been found that garlic has a wide antimicrobial spectrum so that it can kill gram-negative and gram-positive bacteria, so it can be used as an alternative treatment for diarrhea. The purpose of carrying out this study was to describe the potential for garlic extract that have an effect on gram-negative bacteria that cause diarrhea, this natural ingredient can be used as a safe alternative treatment to treat infectious diseases that cause gram-negative bacterial diarrhea. This research method is Narrative review (Literature review). In a journal that discusses the effectiveness of garlic as an antimicrobial regarding the antibacterial activity of thiosulfinates using the petri plate diffusion test, the efficacy of the substances cannot be compared with each other because the assumed diffusion rates are different. In the journal on Comparison of the antibacterial activity of thiosulfinates using the petri plate diffusion test, the efficacy of the substances cannot be compared with each other because the assumed diffusion rates are different. The results showed that the MIC and MBC results of each bacteria given garlic extract were different, even though they were both gram-negative bacteria. Garlic extract has the highest effectiveness on E. coli bacteria based on in vitro studies conducted, compared to Salmonella, Shigella, V. cholerae bacteria according to the characteristics of these bacteria