Primary pancreatic lymphoma (PPL) is a rare condition often confused and diagnosed as a pancreatic malignancy due to the similarity in clinical presentations of the two entities. Patients of PPL may present with features of obstructive jaundice. Here, we discuss the case of a 27-year-old male who presented to the hospital with features of obstructive jaundice, cholangitis, swelling over the scalp, and right scapular region. The patient was diagnosed to have a pancreatic head mass with radiological investigations. Endoscopic ultrasonography (EUS)-guided fine-needle aspiration cytology report was inconclusive, and the final diagnosis of PPL was made after a cervical lymph node biopsy. The patient received treatment with rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisolone regimen and went into remission.
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