Background COVID-19 devastated the routine life of all human kind since its discovery in Wuhan, China in 2019 and caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infections. Vaccination is an effective means for controlling the communicability of the disease and every effort has to be done to increase the proportion of vaccinated people against COVID-19.   Objective The main objective of this study was to assess the willingness of teachers to receive COVID-19 vaccine and its associated factors in dambi dollo town, 2022. Methods School based cross sectional study design was applied. The data were collected self-administered questionnaire and analysed by SPSS version 23.0. Variables which showed association with dependent variable  in  the  bivariate  analyses  at  0.25 were entered  into  multiple  stepwise  logistic regression model.  P- Value 0.05 was considered statistically significant in this study. Adjusted Odds  ratios  together  with  corresponding  95%  confidence  intervals  was used  to  interpret  the findings. Results About 92% of the teachers in dambi dollo town have heard covid-19 vaccine and 67.2% of them know that the vaccine can prevent the COVID-19 disease. On the other hand 51 %( 95%CI: 44.8, 57.2) of the respondents had good knowledge about COVID-19 vaccine. From the total 247 participants who have responded to our inquiry on their willing to receive the COVID-19 vaccine, 68.4% (95%CI: 62.5, 74.3) of them were willing to receive the vaccine immediately while the remaining were either not willing or not ready at the time of data collection. Those participants having good knowledge of the vaccine were about six times more willing to get vaccinated, (AOR=5.85, 95%CI: 2.74, 12.47) in comparison with those having poor knowledge of the vaccine. Conclusion In conclusion, the level of willingness to receive the COVID-19 Vaccine was 68.4% and relatively low in the current study population and participants’ religion and knowledge status are the two variables significantly associated with willingness to receive the vaccine.