Background:The glucocorticoid receptor cross-talks with other receptors to integrate cell signaling. Results: Glucocorticoids and GnRH synergistically up-regulate select mRNA levels via protein kinase C and flotillin-1 to repress cell proliferation. Conclusion: Cross-talk between membrane-associated receptors modulates protein kinase C-dependent synergistic and genespecific transcription by intracellular glucocorticoid receptor. Significance: Glucocorticoid and GnRH receptor cross-talk integrates adrenal and gonadal signaling to fine-tune cell proliferation.