To overcome the disadvantages of mechanical valves and bioprostheses, especially in the mitral position, transplantation of an allogeneous mitral valve was performed in 3 patients. One transplant had to be removed 8 weeks postoperatively, most probably due to maladjustment of the anterior leaflet during surgery. The histology of this specimen showed not clear signs of rejection. In 2 patients, echocardiography showed a normal motion pattern of the mitral valves 6 months postoperatively. Regurgitation was less than 10% of the total stroke volume as calculated by videodensitometry. Both patients were in excellent clinical condition. Mitral valve transplantation can be performed with excellent short-term results. Further studies including immunologic monitoring are necessary to evaluate the long-term behavior of the transplant.

The aortic root as a functional unit includes the sinuses of valsalva, valve ring, the leaflets and the commissures. This unit is impaired by the insertion of a bioprosthetic three-leaflet valve. Moreover, bioprostheses fail because of fatigue and flexion stresses. Consequently a program was started for free-handed orthotopic transplantation of allogeneous aortic valves at the Department of Cardiovascular Surgery, University Kiel. A series of 16 consecutive antibiotic, sterilized aortic valve allografts were transplanted in the last 12 months without death. There were 4 females and 12 males between 18 and 63 years old (mean 47.9). The dominant lesion was aortic regurgitation (in 9), stenosis (in 3) and mixed (in 4). Out of the 13 patients who maintained their allografts, 10 (77%) were in class III and 3 (23%) in class IV of the NYHA functional classification. Four patients improved from class III to class I, and 9 from class III and IV to class II of the NYHA functional classification after surgery. All patients except one had postoperative recatheterization including videodensitometry to quantitate the regurgitation, expressed as a regurgitant fraction ( RGF ) in percent of the total stroke volume of the left ventricle, and pressure measurements to determine systolic gradients across the aortic valve allograft, 3 to 6 days and 9 months after surgery. Eleven (68.75%) patients had no regurgitation, 2 (12.5%) patients had trivial aortic regurgitation with RGF of 7% and 10%, respectively. Three (18.75%) patients had severe aortic valve regurgitation with RGF between 40% and 60% due to technical errors and their allografts had to be replaced.(ABSTRACT TRUNCATED AT 250 WORDS)

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