No abstract

The loess‐soil sequence in northern China contains a near continuous record of Quaternary paleoclimate. Magnetic susceptibility and grain size have so far been the only proxies available to address the long‐term changes of the East‐Asian paleomonsoon extending back to more than one million years. In this study, the ratio of CBD (citrate‐bicarbonate‐dithionite)‐extractable free Fe2O3 (FeD), a measure of iron liberated by chemical weathering, versus the total Fe2O3 available (FeT) was measured on samples at 10 cm intervals taken from two loess sections deposited over the last 1.2 Ma. Variations of this index are highly consistent with other pedological indicators, but in addition provide a quantitative measurement of the degree of pedogenesis in the Loess Plateau. Since chemical weathering in the region mainly depends upon summer precipitation and temperature, weathering intensity primarily reflects changes in the East‐Asian summer monsoon. The new proxy has been used to document a series of summer monsoon changes of global significance, which are not necessarily recorded by magnetic susceptibility.

Ferroelectrics, which generate a switchable electric field across the solid–liquid interface, may provide a platform to control chemical reactions (physical properties) using physical fields (chemical stimuli). However, it is challenging to in-situ control such polarization-induced interfacial chemical structure and electric field. Here, we report that construction of chemical bonds at the surface of ferroelectric BiFeO3 in aqueous solution leads to a reversible bulk polarization switching. Combining piezoresponse (electrostatic) force microscopy, X-ray photoelectron spectroscopy, scanning transmission electron microscopy, first-principles calculations and phase-field simulations, we discover that the reversible polarization switching is ascribed to the sufficient formation of polarization-selective chemical bonds at its surface, which decreases the interfacial chemical energy. Therefore, the bulk electrostatic energy can be effectively tuned by H+/OH− concentration. This water-induced ferroelectric switching allows us to construct large-scale type-printing of polarization using green energy and opens up new opportunities for sensing, high-efficient catalysis, and data storage.

T-cell lymphoblastic lymphoma (T-LBL) is a heterogeneous malignancy of lymphoblasts committed to T-cell lineage. Dismal outcomes (15-30%) in case of T-LBL relapses warrants for establishing risk-based treatment in future. This is a first comprehensive, systematic, integrated genome-wide analysis including relapse cases aimed towards identifying molecular markers of prognostic relevance for T-LBL. NOTCH1 was identified as putative driver for T-LBL. Activated NOTCH/PI3K-AKT signaling axis and alterations in cell cycle regulators constitutes the core oncogenic program for T-LBL. Mutated KMT2D was identified as a prognostic marker. The cumulative incidence of relapse was 47±17% in patients with KMT2D mutations compared with 14±3% in KMT2D wildtype. Structural analysis of the mutated domains of KMT2D revealed plausible impact on the structure and functional consequences. These findings provide new insights into the pathogenesis of T-LBL including high translational potential. The ongoing trial LBL 2018 (NCT04043494) allows prospective validation and subsequent fine-tuning of the stratification criteria for T-LBL risk groups to improve survival of the pediatric patients.