Background: Hashimoto's thyroiditis (HT) is classify within the autoimmune disease of thyroid gland caused by diffuse of special lymphocytes into thyroid, lymphocyte product's special antibody lead to destroy gland tissue . Vitamin D (vit.D) is steroid substance bind with special receptor to have it's functions .Vit.D3 has various function in human body such as non skeletal function of vit.D3 is gene regulation that involve in autoimmune disease.Materials and methods: Present study include collection involved tow groups , HT disease group and healthy individuals , then measured vit.D3 , T4, TSH and anti-TPO levels for all groups.Results: Study result's shown after comparison between HT patients group and control group the reduction of serum vit.D level at HT group with present hypofunction of thyroid gland .Conclustion : Concluded this study to must be serumvit.D3 level within normal rang due to vit.D3 has function to regulation genes that effect on autoimmune diseases such as HT via modulation of immune cells secretions that lead to thyroid cells destroy.

Subject: Polycystic ovary syndrome (PCOS) is female disorder caused by cysts formation in ovarian that results disorder of hormones secretion and menstrual cycle. Neuregulin 4 (NRG4) is one of adipokines family members synthesis and release via adipose tissues, it acts as activator the epidermal growth factor receptor (EGFR).Objective of the Study: Assessment role of NRG4 in PCOS patients.Materials and Methods: Present study included 30 PCOS patients with 30 controls, the age individuals of tow group at study were 18 years and above of females. At this study measured serum NRG4 level by quantity method for all study individuals, the body mass index (BMI) also measured for all study individuals.Results: Present study explain increase of NRG4 level in serum samples and BMI in PCOS patients group compared with control group.Conclusion: Current study demonstrate role of NRG4 level that act as compensate mechanism in PCOS disorder.