BackgroundThe closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection. The objective of this paper was to study seasonal variations in AAV with respect to renal affectation diagnosed in Catalonia, Spain.MethodsTwo hundred and thirty-four patients diagnosed for renal AAV between 2001 and 2014 in eight hospitals in Catalonia were included in the study. We used medical records to retrospectively analyse the date of the first symptoms attributed to the AAV, ANCA subtypes, the degree of renal impairment and renal histology.ResultsOf the 234 patients studied, 49.2% were male and 50.8% female. For ANCA status, 8.5% were positive, 15.9% were proteinase-3-positive and 75.6% were myeloperoxidase-positive. In relation to histological classification, 17.8% were sclerotic, 11.7% focal, 38.8% crescentic and 31.7% mixed. Regarding seasonal distribution, we observed a clear seasonal periodicity with a significantly higher incidence of cases in the winter. Applying an Eigen decomposition, we observed a periodic fluctuation of frequencies around the annual cycle with peaks every 10–12 months, and higher incidence of AAV cases in February.ConclusionsOur results confirm, in Catalonia, the seasonal periodicity of AAV with a higher incidence in the winter, as formerly described in the literature for other regions. An environmental factor, likely one that is infectious, may explain this finding.

Objective: to describe the profile of individuals with lip cancer diagnosed in 2020 residing in Minas Gerais. Methods: descriptive study with a quantitative approach. Clinical and epidemiological data of individuals with lip cancer diagnosed in 2020 residents in Minas Gerais were evaluated. Inclusion criteria were data available in the system and incomplete data were excluded. An analysis of the data available in the hospital records of the Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) was carried out in the most recent historical series, and a descriptive analysis of the data was performed. The study was carried out during the month of June 2022. Results: in the analysis of the most recent data recorded in the INCA hospital records system, 70 cases of lip cancer were reported, the male sex was the most predominant (65.8%) , the most frequent age groups were respectively 60 to 64 years (14.2%), 70 to 74 years (12.8%) and 75 to 79 (17.1%), the white color was the most frequent (51, 4%), with incomplete primary education also the most common (44.2%), married marital status (45.7%) was the most recorded. The history of tobacco use was present in most cases (51.4%), in relation to the histological type, squamous cell carcinoma predominated (87.1%), with TNM staging classified as 1 more commonly (35.7%). registered and the most used therapeutic modality was surgery (65.7%) to the detriment of chemotherapy and radiotherapy. Conclusion: the data indicated male patients in an advanced age group, white and married with low education. There was an association between smoking and the diagnosis of cancer, with squamous cell carcinoma being the most frequent, with surgery being the most used therapeutic modality.

Objective: to describe the profile of individuals residing in Montes Claros with oral cancer in the 2015/2019 historical series. Method: descriptive study with a quantitative approach. Clinical and epidemiological data of individuals with oral cancer residing in Montes Claros, Minas Gerais were evaluated. Inclusion criteria were data available in the system and incomplete data were excluded. An analysis of the data available in the hospital records of the Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) was carried out in the most recent historical series, and a descriptive analysis of the data was performed. The study was carried out during the month of June 2022. Results: in the analysis of the years 2015 to 2019, 312 diagnoses of oral cancer were recorded. 17.2% of individuals were female and 82.8% were male, the predominant age ranged from 50 to 69 years (55.6%), family history of cancer was negative in 37.7% of those investigated . 48.4% of the patients used tobacco or derivatives, the combined use of tobacco and alcoholic beverages was present in 83.4 of the cases. Regarding the clinicopathological variables, the highest rate corresponded to squamous cell carcinoma (97.4%), with TNM staging classified as 4 A (46.4%) more frequently and with primary location in the tongue or base of it (51, 7%). Conclusion: the data predominantly indicate male patients, aged between 50 and 69 years and without a family history of cancer, alcoholism and positive smoking, in addition to advanced carcinogenesis.

Introduction: Cancer of the oral cavity is a malignant tumor that can occur in the lips, oral structures and region under the tongue. They are cancers that often affect male patients aged 40 years and over. Objective: To describe the clinical and epidemiological profile of patients diagnosed with oral cavity cancer from 2015 to 2019 in Montes Claros, Minas Gerais, Brazil. Methods: A descriptive study of quantitative approach was conducted through data from patients living in Montes Claros, Minas Gerais with diagnosis of oral cavity neoplasia in hospital records of the José Alencar Gomes da Silva National Cancer Institute (INCA). Results and discussion: In the historical series analyzed, 312 cases of cancer of the oral cavity were identified. Conclusion: The patients who were diagnosed with cancer in the oral cavity were mostly men aged between 50 and 69 years, the association between concomitant use of tobacco and alcoholic beverages was present in the vast majority of cases. Health professionals' efforts are needed for early diagnosis through educational actions and primary prevention.