The aim of this study was to analyze the glomerular and tubular alterations in dogs with terminal distemper through light microscopy, immunofluorescence, and electron microscopy. Thirteen animals with a molecular diagnosis of distemper and neurological signs were selected. As a control group, 10 clinically healthy animals with no manifestations or signs of disease and with negative tests for Ehrlichia sp., Anaplasma sp., and Babesia sp. were included in this study. Renal tissue was evaluated by light microscopy, topochemistry for DNA/chromatin, and video image analysis to detect the nuclear phenotypes of the renal tubular epithelial cells (RTECs), immunofluorescence, and transmission electron microscopy. Results showed that dogs with distemper exhibited anemia, hypergammaglobulinemia, and proteinuria. Creatinine in the distemper group was lower compared to the control group (p = 0.0026), but there was no significant difference in relation to urea (p = 0.9876). Although this alteration may be due to the smaller muscle mass observed in animals with distemper, it probably is not of clinical importance. Glomerular and tubular lesions were confirmed by light microscopy in 84.6% of these animals. Additional findings in the animals with distemper included deposition of different classes of immunoglobulins, particularly IgM in 92.3% of the cases, fibrinogen deposition in 69.2% of the cases as assessed by immunofluorescence, alterations in the nuclear phenotypes of the RTEC characterized by condensation of chromatin, loss of DNA and reduction in the nuclear shape, and the presence of subendothelial and mesangial electron-dense deposits. These findings confirm the existence of renal alterations related to terminal distemper.
Lesões do tipo shunt no septo que separa as duas câmaras atriais estão entre as malformações cardíacas congênitas mais comuns. Na maioria dos casos, estão associadas a altas taxas de morbidade e mortalidade. Uma cadela, sem raça definida, de 12 anos de idade foi encaminhada para consulta devido a sintomas como intolerância ao exercício e aumento de volume abdominal. O exame ecocardiográfico revelou comunicação interatrial do tipo ostium secundum (shunt da esquerda para a direita). A paciente sobreviveu por 8 meses após o diagnóstico. Durante a necropsia, foi detectado um defeito de 21 mm de diâmetro no septo atrial. Com base na localização, foi confirmada a comunicação interatrial tipo ostium secundum. A peculiaridade deste caso é que a paciente viveu por mais de 13 anos, em estado assintomático, com uma comunicação interatrial de amplo diâmetro, em comparação com seu porte e peso.
Transplants for cats with naturally occurring renal disease have been introduced into clinical practice, but canine renal transplantation represents a greater challenge because of the lack of a balanced immunosuppressive protocol, difficulty in selecting compatible canine kidney donors, and absence of transplantation monitoring protocols. This and other important factors will be discussed in this review to help improve short- and long-term outcomes for renal transplantation in dogs.
Complicações relacionadas à ausência do reparo cirúrgico de fraturas pélvicas podem resultar em obstipação crônica, fecaloma e estreitamento do canal pélvico. Assim, o objetivo do presente relato foi descrever as complicações e tratamento de um caso de estenose do canal pélvico decorrente da ausência de redução e fixação de corpo de ílio em uma cadela, com sete meses de idade, com 10 kg, não castrada e sem raça definida, com sinais clínicos de obstipação, tenesmo e dor atendida no Hospital Veterinário da Universidade de Franca (UNIFRAN -SP) que respondeu favoravelmente ao tratamento cirúrgico instituído.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.