No abstract

No abstract

A cross-sectional study of secondary data/information obtained from the Hospital Information System (HIS) spanning the years 2008 -2009 was performed. The distribution of the main hospital admissions by gender, age, color/race, region and federal unit of residence, average expenditure and average length of hospital stay, year of hospitalization and mortality rates (MR) were studied. The data collected were tabulated by TabNet and keyed into Microsoft Excel 2007. It was verified that elderly males (54.3%), from 60 to 69 years old (50.6%), nonwhites (36.3%) and residents of Southeast and North regions of the country had the highest rates of hospitalization. Seniors were hospitalized for an average of 4.8 days, and the major causes were exposure to alcohol (43.7%) and to drugs (33.9%). Expenses related to hospital admissions were, on average, R$ 529,817.70. The highest mortality rates were recorded among females (MR = 4.34), in elderly, 80 years or older (MR = 10.16) and Caucasians (MR = 3.95), where pharmacological substances with action on the Autonomic Nervous System were the leading cause of death. There are demographic differences in morbi-mortality of these elderly since, although men and younger elderly were the main victims, women and elderly of advanced age have greater mortality. The leading causes of hospitalization were alcohol and drugs.Uniterms: Hospital Information System. Elderly patients/hospitalization. Medicines/inappropriated use. Hospitalization/rates. Poisoning. Alcohol/use.Realizou-se um estudo transversal de dados secundários obtidos no Sistema de Informação Hospitalar (SIH), nos anos 2008/2009. Estudou-se a distribuição das principais internações segundo sexo; faixa etária; cor/ raça; região e unidade federativa de residência; valor médio pago e média de permanência das internações hospitalares; ano de internação e as taxas de mortalidade (TM). Os dados coletados foram tabulados por meio do TabNet e transcritos para o Programa Microsoft Excel® 2007. Verificou-se que idosos do sexo masculino (54,3%), com 60 e 69 anos de idade (50,6%), não brancos (36,3%) e residentes nas regiões Sudeste e Norte do País apresentaram os maiores percentuais de internação hospitalar. Idosos ficam em média 4,8 dias internados, sendo as principais causas a exposição ao álcool (43,7%) e a medicamentos (33,9%). Os gastos com as internações equivaleram a R$ 529.817,70. As maiores taxas de mortalidade foram registradas no sexo feminino (TM=4,34), em idosos entre 80 anos e superior (TM=10,16) e pessoas brancas (TM=3,95), sendo as substâncias farmacológicas de ação sobre o Sistema Nervoso Autônomo maiores causas do óbito. Existem diferenças demográficas na morbimortalidade desses idosos, visto que apesar de homens e idosos mais jovens serem as principais vítimas, mulheres e idosos com idade mais avançada morrem mais. Sendo as principais causas de internação o álcool e os medicamentos.Unitermos: Sistema de Informação Hospitalar Paciente idosos/hospitalização. Medicamentos/uso inapropriado. Hospitalização/causas. Envenena...

aims: The synthesis and antitumor activity of phenoxy-hydrazine-1,3-thiazoles derivatives background: Cancer is one of the most important barriers to increasing life expectancy in every country of the world in the 21st century. The investigations of new anticancer drugs with low side effects are an urgent demand for medicinal chemists. objective: Considering the known antitumor and immunomodulatory activity of thiazoles, this work presents the synthesis and antineoplastic activity of new thiazoles. method: The 22 new compounds (2a-v) were synthesized from different thiosemicarbazones and 2-bromoacetophenone. The compounds were evaluated on: MOLT-4, HL-60, HL-60/MX1, MM1S, SKMEL-28, DU145, MCF-7, and T47d. result: Compound 2b induced cellular viability of less than 59% on MOLT-4, DU145, and HL-60/MX1 cells. On MOLT-4 cells, compound 2b exhibited an IC50 of 8.03 μM, and against DU145 cells an IC50 of 6.04 μM. Besides, at IC50 and fold of IC50, 20% to 30% of dead cells were found, most of which were due to necrosis/late apoptosis. Most parts of the compounds showed no cytotoxicity against fibroblast cells L929 at concentrations up to 400 μM. The compound does not appear to significantly influence the cell cycle by using IC50 and twice IC50 values. Therefore, compound 2b stands out against DU145 and MOLT-4 cells. conclusion: Our study reinforced the importance of 1,3-thiazoles nuclei in antitumor activity. In addition, derivative 2b stands out against DU145 and MOLT-4 cells and could be used as a starting point for the development of new antineoplastic agents. other: 1,3-Thiazoles; Bioisosterism; Cancer; DU145; MOLT-4; Antitumor.