OBJECTIVE -To assess associations between peripheral sensory neuropathy (PSN) and other diabetes-related complications.RESEARCH DESIGN AND METHOD -In an area-based cohort of type 2 diabetic subjects, we investigated 156 subjects (age 61.7 Ϯ 7.2 years and diabetes duration 7.0 Ϯ 5.7 years) by questionnaires, clinical examinations, blood and urine sampling, and review of medical records.RESULTS -Prevalence of PSN, assessed by monofilament and neurothesiometer testing, increased with severity of retinopathy (50% frequency in moderate and 100% in severe or proliferative retinopathy; P ϭ 0.02). Vibration perception threshold was higher in subjects with retinopathy (25.6 Ϯ 8.9 vs. 20.5 Ϯ 8.9 V; P ϭ 0.007). PSN was more common in subjects with overt nephropathy, with higher vibration perception thresholds, than in subjects without overt nephropathy. Subjects with PSN but no retinopathy had twice the prevalence of peripheral vascular disease (PVD) (52%) as subjects with both PSN and retinopathy (19%; P ϭ 0.05). In subjects with PSN alone, PVD was three times more likely (52%) than in subjects without PSN (16%; P ϭ 0.001). In multivariate analysis, PSN was independently associated with PVD (odds ratio 2.31; P ϭ 0.007), age (1.12; P ϭ 0.008), male sex (2.01; P ϭ 0.02), and HDL cholesterol (0.21; P Ͻ 0.05) and tended to be independently associated with IGF-1 binding protein (1.03; P ϭ 0.05) but not with diabetes duration or A1C.CONCLUSIONS -In a representative population of type 2 diabetes, PSN is related to microvascular and macrovascular pathology. PSN is possibly affected by the IGF axis.

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Background: Insulin-like growth factor-binding protein 7 (IGFBP-7) is able to interact with insulin-like growth factor 1 (IGF-1) as well as insulin. Previous studies have suggested that serum IGFBP-7 levels may be associated with insulin resistance in type 2 diabetes (T2D). This study aimed to evaluate IGFBP-7 serum protein and IGFBP7 DNA methylation levels in the subjects with and without T2D.