Employing the three-pore model of peritoneal transport and taking into account the polydispersed nature of ICO, it was possible to accurately computer simulate the UF profiles of ICO in accordance with reported data. The simulations suggest an advantage of using ICO in patients with type I UF failure, where UF with a high-MW osmotic agent will exceed that seen in patients not showing UF failure who are on glucose-based PD solutions.

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Introduction: Despite clinical guidelines and high-quality imaging an inherent imprecision exists in accurate preoperative diagnosis of serous cystic neoplasms (SCN). SCN can mimic premalignant or malignant lesions resulting in misdiagnosis. The aim of this study was to determine the clinical and diagnostic features that precipitated the incorrect diagnosis of SCN. Methods: Data for all patients who underwent a pancreatectomy with an unintended diagnosis of SCN from January 2005eJuly 2015 was retrospectively reviewed. Results: Among a total of 155 patients who underwent pancreatectomy for a SCN, the preoperative diagnosis was unclear in 128 (83%). Of 128 patients, 70 (55%) were thought to represent malignancy, 46 (36%) were felt to be either PNET or a mucinous cystic and the etiology was unknown in 12 (9%). A total of 105 (82%) patients had diagnostic studies performed at JHH available for review, 101 (96%) CT, 18 (17%) MRI and 31 (30%) EUS. Of 105 patients, 34 (32%) SCN were macrocystic, 23 (22%) microcystic, 17 (16%) mixed, 16 (15%) solid-type or type unspecified in 15 (14%). Among 105 patients, a solid component was described in 32 (30%) patients by CT/MRI and was confirmed on EUS in 3 (9%) patients. A solid component was diagnosed on EUS alone in 3 (9%) patients. Cyst fluid analysis was available for 13 (12%) patients and mucin was seen in 9 (69%). The median cyst fluid CEA was 1 ng/mL (IQR, 0e4.1). Conclusion: SCN are often confused with malignant or premalignant lesions preoperatively. High-quality CT, MRI and EUS are useful but inadequate to consistently differentiate SCN from lesions requiring resection. Molecular markers are necessary to further aide in the preoperative diagnosis of SCN.