Nuclear magnetic resonance (NMR) proton imaging and measurements of the parameters T1 and T2, have been carried out in vivo on the murine mammary tumour T50/80. Tumours had been treated 24h previously by photodynamic therapy (PDT, using haematoporphyrin derivative and 630nm laser light). Proton images clearly demarcated a high signal-intensity region on the side of the tumour closest to the incident light beam, while the parts of the tumour more remote from the beam resembled the images from untreated controls. Both T, and T2 values were raised in the high-intensity region. This high-intensity region was shown to correspond to PDT-induced histological necrosis, the low-intensity region to histologically intact tumour. Linear regression analysis of the relationship of depth of necrosis measured histologically and 'depth of necrosis' measured from the NMR images, yielded a slope of 0.93 (r2=0.95).

The Motorik-Modul (MoMo) Longitudinal Study aims to contribute to long-term improvement in the health of German children and adolescents by focusing on: (i) the development of physical fitness and physical activity (including period effects); (ii) the individual and physical/social environmental determinants of the development of physical fitness and physical activity; and (iii) the impact of physical fitness and physical activity on the development of physical and mental health. The MoMo Longitudinal Study began with a nationwide representative sample of 4529 children and adolescents who ranged in age from 4-17 years at the study baseline (2003-2006). The first survey wave of the MoMo Longitudinal Study was conducted between 2009 and 2012, with two subsequent survey waves to be conducted between 2014 and 2016 and 2018 and 2020, respectively. The MoMo Longitudinal Study includes a physical fitness test profile, a physical activity questionnaire, and subjective and objective measures of health from the German Health Interview and Examination Survey (KiGGS). Data access is provided on request (alexander.woll@kit.edu). For further information, including a complete list of publications please visit www.motorik-modul.de.

The paper deals with the design of Smart Learning Environments (SLEs). Over and above that, it's about the interconnection between SLEs and the internet of things. With the question of how an interdisciplinary approach can contribute to the design of SLEs together with the disciplines of education, computer science and architecture the study empirically applies data collected in 2016. The empirical research was initiated by consolidating the findings from transdisciplinary analyses of the literature in a hypothetical model for designing SLEs. This model pooled success factors from different spheres of influence and served as a tool for empirical research. A triangulation was used for facilitating a model-validation in the context of 7 expert interviews, 7 questionnaires as well as a workshop with training experts. The data analysis resulted in the development of a holistic, socio-technical framework.

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