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Novel nonsymmetrical N-bi- and N-terarylpiperazines were synthesized on solid phase via three consecutive palladium-catalyzed cross-coupling reactions in which C-N, C-B, and C-C bonds are formed consecutively.

Carbohydrates Carbohydrates U 0500Synthesis of Two D-Glucosamine Derived 3,4-Epoxides as Potential Scaffolds for Combinatorial Chemistry. -Two stereoisomeric D-glucosamine derived 3,4-epoxides (X) and (XIV), potential scaffolds for combinatorial chemistry applications, are synthesized in 5 and 6 steps, resp., from 2-acetamido-α-D-glucopyranoside (I). The stereochemical orientation of the epoxide is controlled through amino protecting group directed regioselective O-tosylation prior to epoxide formation. Moreover, preliminary studies on the opening of epoxide (XIV) in solution are described. -(SVEJGAARD, L.; FUGLSANG, H.; JENSEN, P. B.; KELLY, N. M.; PEDERSEN, H.; ANDERSEN, K.; RUHLAND, T.; JENSEN*, K. J.; J. Carbohydr. Chem. 22 (2003) 3-4, 179-184; Chem. Dep., R. Vet. Agric. Univ., DK-1871 Frederiksberg, Copenhagen, Den.; Eng.) -M. Kowall 38-176