Here, butylene adipate-co-terephthalate/polypyrrole with nanohydroxyapatite (PBAT/PPy/nHAp) scaffolds were fabricated and characterized. The electrospinning process was carried out using 12 kV, a needle of 23 G, an infusion pump set at 0.3 mL/h, and 10 cm of distance. Afterwards, nHAp was directly electrodeposited onto PBAT/PPy scaffolds using a classical three-electrode apparatus. For in vivo assays (comet assay, acute and chronic micronucleus), 60 male albino Wistar rats with 4 groups were used in each test (n = 5): PBAT/PPy; PBAT/PPy/nHAp; positive control (cyclophosphamide); and the negative control (distilled water). Peripheral blood samples were collected from the animals to perform the comet test after 4 h (for damage) and 24 h (for repair). In the comet test, it was shown that the scaffolds did not induce damage to the % DNA tail and neither for tail length. After the end of 48 h (for acute micronucleus) and 72 h (for chronic micronucleus), bone marrow was collected from each rat to perform the micronucleus test. All of the produced scaffolds did not present genotoxic effects, providing strong evidence for the biological application of PBAT/PPy/nHAp scaffolds.

Objetivo: Avaliar os efeitos de cicatrização da Moringa oleifera em ratos Wistar. Metodologia: Folhas da moringa foram coletadas, secas, trituradas, misturadas com solvente hexano e filtrada. Após remoção do solvente e da umidade, combinou concentrado resultante ao gel natrosol, alcançando concentrações de 5% e 10%. Dividiu-se 60 ratos machos em 4 grupos: controle negativo (sem tratamento), controle positivo (tratados com AGE), Moringa 5% (tratados com gel de Moringa a 5%) e Moringa 10% (tratados com gel de Moringa a 10%). Subdividiu-se em três grupos de 5 animais de acordo com período de avaliação (7, 14 e 21 dias). Realizou-se na região cervical uma incisão longitudinal (3,0 cm); na região dorsal foi demarcada e ressectada uma área de 2 cm² com um punch. Resultado: Na análise da resistência cicatricial, após 7 dias, os grupos moringa 5% e 10% mostraram uma regressão significante; após 14 e 21 dias, o grupo Moringa 10% apresentou significância estatística quando comparado aos demais grupos. Na análise microscópica, após 7 dias, fibras colágenas mais evidentes nos grupos Moringa 5% e 10%; após 14 e 21 dias, poucos vasos sanguíneos, reação inflamatória de baixa intensidade e deposição de colágeno mais organizada e intensa no grupo Moringa 10%. Conclusão: A moringa, especialmente na concentração de 10%, mostrou-se benéfica no processo reparativo de feridas cutâneas cirurgicamente induzidas em ratos.

Commiphora leptophloeos (Burseraceae) is a plant belonging to the genus Commiphora popularly known as imburana or umburana. It found in the caatinga and cerrado of Brazil. The species belonging to the genus Commiphora are used in folk medicine as anti-inflammatory, antimicrobial and in the treatment of several diseases. In recent decades, cases of diseases caused by the Aedes aegypti mosquito have increased considerably, making it necessary to seek alternative measures to combat the vector. The present study aimed to analyze, through bibliographic review, Commiphora leptophloeos regarding aspects of family, genus and species; and describe the relationship of this species with Aedes aegypti, highlighting natural products in the control. The findings indicate repellent activity of species of the genus Commiphora on insects, in addition to the presence of some mono and sesquiterpenes compounds, widely distributed in the genus, among them α-pinene, camphene and β-pinene. Studies also confirm the ethnobotanical uses of C. leptophloeos, as well as its potential in the treatment of diseases. The analyzed literature indicates the antimicrobial activity of the aqueous extract of the bark and stem of C. leptophloeos against Staphylococcus epidermidis. Other data reveal that the essential oil of this species has larvicidal and deterrent activity against A. aegypti. The revised literature suggests the importance of natural products, their advantages as biopesticides, as well as the effectiveness of C. leptophloeos in combating the A. aegypti mosquito, stressing the need for further studies and tests to isolate the compounds present in this species.

Objective: To evaluate the possible antidepressant effects of alpha-terpineol in rodents. Material and Methods: Depression levels were analyzed by comparing the total immobility time presented by the animals of the experimental groups in the test session, using the Forced Swimming Test and the Tail Suspension Test. The parameters of locomotion (central, peripheral and total) and motor coordination were evaluated in the Open Field Test and in the Rota Rod Test, respectively. In the second stage, the involvement of the noradrenergic system in the antidepressant action of alpha-terpineol in Forced Swimming Test was investigated. Results and Discussion: After performing the experimental tests, it was observed that the animals that received alpha-terpineol had reduced immobility time in Forced Swimming Test and Tail Suspension Test, compared to the other groups. In the Open Field Test and Rota-rod, the mice showed, respectively, good exploratory activity and motor coordination during the tests. In addition, the study of the Noradrenergic System proved to be a promising mechanism used during its antidepressant action. Conclusion: In view of the results of the experimental tests, alpha-terpineol presented similar responses to those found in other monoterpenes investigated in the literature. Thus, it is shown as a promising antidepressant to be used clinically in humans, with less side effects and low production cost.

Objective: In this scientific study, we aimed to evaluate genotoxic effects in rats (Rattus norvegicus), related to different periods of exposures to the LED curing light. Methodology: For the genotoxicity evaluation, the rats received lights from the LED photopolymerizer for 40 sec, 10 min and 7-and-a-half minutes, while the negative and positive control groups were treated with distilled water and cyclophosphamide by intraperitoneal, respectively. A sample of peripheral blood was collected from the animals for the comet assay. The bone marrow was collected from each rat for the micronucleus test. Results: It was observed that in the comet assay and micronucleus test, the animals exposed to LED for 10 min, showed genotoxic damage, and they have not presented toxicity degree in the periods of 40 sec and 7-and-a-half minutes. Conclusion: It is possible to conclude that, there was genotoxic effects on the animals' teeth when exposed to the LED curing light in 10 min. However, in the periods of 40 sec, and 7- and-a-half minutes, have been not observed genotoxic effects. This means these times are safe for professional dentists in clinical care.