The purpose of this study is to determine the antioxidant activity, antiproliferation, apoptosis, and cell cycle arrest induced by Coleus tuberosus flesh and peel extracted with ethanol. The antioxidant activity was determined using the 1,1-diphenylpricrylhydrazyl and cellular antioxidant assays, and the antiproliferative activity was determined using the 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Flow cytometry was used to assess cell cycle arrest, and acridine orange-ethidium bromide staining was used to assess apoptosis-induced ability. The results show that the C. tuberosus peel extract has higher antioxidant activity than the flesh extract. Coleus tuberosus flesh ethanol extract (CFEE) and C. tuberosus peel ethanol extracts' (CPEE) antioxidant activities inhibitory concentration 50 (IC 50 ) were 1290.00±1.58g/ml and 310.97±0.32µg/ ml, respectively. The C. tuberosus peel extract has greater antiproliferative activity than the flesh extract. The C. tuberosus flesh and peel extracts had antiproliferative activities (IC 50 ) of 651.35±4.24 and 366.41±3.52µg/ml, respectively. The flesh and peel extracts cause apoptosis in HeLa cells. Cell cycle arrest in sub-G1 (M) and cell cycle inhibition in G0-G1 are caused by the C. tuberosus peel extract. According to this study, the CFEE and CPEEs have the potential to be a source of natural antioxidants and antiproliferation of cervical cancer.