Benzhydrazone half-sandwich platinum group metal complexes were prepared by the reaction of metal precursors and benzhydrazone derivative ligands which yielded chelating N∩O and N∩N bidentate cationic complexes. Ruthenium complexes formed N∩O while rhodium and iridium complexes formed N∩N bonding modes respectively. Antibacterial activity (against Grampositive and Gram-negative bacteria) as well as anti-cancer (HCT116 p53 +/+ and HCT116 p53-/-) studies for these complexes were carried out.
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