Anti-Neutrophil Cytoplasmic Antibody (ANCA)-negative Rapidly Progressive Glomerulonephritis (RPGN) is a severe form of autoimmune renal injury with a bleak prognosis. A 60-year-old Indian woman was treated with classical homeopathy for ANCA-negative RPGN, and after one year of treatment, serum creatinine and other parameters indicating renal injury dropped steadily despite the withdrawal of immunosuppressive drugs; renal dialysis, which was conducted twice a week initially, was made rarer and stopped after one year. Classical homeopathy may be considered a potential therapeutic modality in severe pathologies. Controlled studies are required to establish further the extent to which classical homeopathy may relieve patients from procedures such as dialysis that cause considerable physical and economic discomfort.

This a preprint and has not been peer reviewed. Data may be preliminary.

Classical homeopathy can be included among the treatment options for congenital heterotopic ossification.

Fever is the hallmark of efficient acute inflammatory response, which may be disrupted in chronic inflammatory conditions. “The Continuum Theory” proposes that the return of acute inflammatory states with high fever herald improvement in chronic diseases during treatment. Our objective was to investigate if a correlation exists between chronic inflammation and efficient acute inflammation. In a case control study, the reports of patients diagnosed with chronic inflammatory conditions with at least 6 months of follow up under homeopathic treatment were retrospectively sampled from homeopathic medical practitioners from Greece, India, Romania, and Russia. 20 patients who improved under homeopathic treatment and 20 age matched controls of those who did not improve were selected. The occurrence of common acute infectious diseases with fever during the follow up period was investigated. The Odds Ratio of improving with respect to development of acute infectious diseases was calculated and graphs were plotted to study the pattern in each case. The average age of the cases and controls was 28.4 and 27.9 years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever respectively. Odds Ratio of improving with respect to development of acute infectious diseases was 36 (95%, CI: 5.7973 to 223.5513), z statistic: 3.846 (p = 0.0001). In this case control study, appearance of common acute infectious diseases with fever was strongly associated with improvement in the chronic inflammatory conditions.

Objective Suppression of efficient acute inflammation may be one of the mechanisms behind the onset of chronic low-grade inflammation. Efficient acute inflammatory response to pathogenic stimulus may not be possible in the presence of chronic inflammation. We investigated if a correlation exists between chronic and efficient acute inflammation. Methods Design Case control study. Setting Homeopathic medical practices in 4 countries Patients with definite improvement in chronic inflammatory conditions with at least 6 months of follow up were selected as cases. Age matched controls involved those who did not improve. Event of interest Occurrence of common acute infectious diseases with fever during the follow up period. Statistical analysis Odds Ratio of improvement in the chronic condition, with development of acute infectious diseases with fever was calculated. Graphs were plotted to study this correlation in individual cases. Results 20 cases and 20 age matched controls were selected. Average age was 28.4 and 27.9 years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever during the follow up period. Odds Ratio of the chronic condition improving, with development of acute infectious diseases with fever was 36 (95 %, CI: 5.7973 to 223.5513), z statistic: 3.846 and significance level was p = 0.0001. Graphs of individual cases showed distinct patterns confirming the same. Conclusions In this case control study, appearance of common acute infectious diseases with fever during treatment was strongly associated with improvement in the chronic inflammatory conditions. Larger studies are needed to further establish the correlation. Supported by Nil