Background SARS-CoV-2 IgG antibody measurements can be used to estimate the proportion of a population exposed or infected and may be informative about the risk of future infection. Previous estimates of the duration of antibody responses vary. Methods We present 6 months of data from a longitudinal seroprevalence study of 3276 UK healthcare workers (HCWs). Serial measurements of SARS-CoV-2 anti-nucleocapsid and anti-spike IgG were obtained. Interval censored survival analysis was used to investigate the duration of detectable responses. Additionally, Bayesian mixed linear models were used to investigate anti-nucleocapsid waning. Results Anti-spike IgG levels remained stably detected after a positive result, e.g., in 94% (95% credibility interval, CrI, 91-96%) of HCWs at 180 days. Anti-nucleocapsid IgG levels rose to a peak at 24 (95% credibility interval, CrI 19-31) days post first PCR-positive test, before beginning to fall. Considering 452 anti-nucleocapsid seropositive HCWs over a median of 121 days from their maximum positive IgG titre, the mean estimated antibody half-life was 85 (95%CrI, 81-90) days. Higher maximum observed anti-nucleocapsid titres were associated with longer estimated antibody half-lives. Increasing age, Asian ethnicity and prior self-reported symptoms were independently associated with higher maximum anti-nucleocapsid levels and increasing age and a positive PCR test undertaken for symptoms with longer anti-nucleocapsid half-lives. Conclusion SARS-CoV-2 anti-nucleocapsid antibodies wane within months, and faster in younger adults and those without symptoms. However, anti-spike IgG remains stably detected. Ongoing longitudinal studies are required to track the long-term duration of antibody levels and their association with immunity to SARS-CoV-2 reinfection.

This paper explores clown pedagogy in relation to authenticity, taking as its starting point the clown workshop at the École Philippe Gaulier in June 2008 in which I was a participant-researcher. I explore how and where an analysis of French clown training both reveals reinscription of authenticity-the idea that the "true self" is revealed through the mask form of clown-and exposes fissures in these ideas. Within this training, I argue, a construct of the authentic self exists alongside techniques that disrupt conventional notions of stable, linear identity by utilising techniques of disorientation to shift the locus of the self from the core of the body to a negotiable space between performer and spectator. Examining the ways in which gestural style was both linked with and contested the idea of authenticity within the French mime tradition in the late nineteenth and early twentieth centuries, I examine how such conflicting ideas of authenticity continue to circulate within the contemporary clown classroom. Specifically, I look at how the pedagogical language used by Gaulier and the descriptive language of students, as well as embodied classroom practices, discursively reinscribe the idea of a stable, unified self while simultaneously disrupting it. By juxtaposing and drawing connections between an older mime tradition and a current pedagogical practice, I wish to highlight the ways in which the idea of the "self" has been and continues to be contested, altered and redefined within a specific site of performer training.

TIC chemotherapy is feasible and tolerable in children and adolescents with refractory/recurrent solid tumors and lymphomas and results in a 43% excellent ORR in this poor-risk group of patients. A larger cohort of patients, especially in Wilms tumor and central nervous system (CNS) tumors, should be studied in the future to attempt to confirm these preliminary findings. Pediatr Blood Cancer 2015;62:274-278. © 2014 Wiley Periodicals, Inc.

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