No abstract

Italy was one of the first industrialized countries to implement a program of routine vaccination against hepatitis B virus (HBV) infection. However, currently, no HBV vaccine is administered at birth if the screened mother is HBsAg negative, whilst babies born to HBsAg positive mothers are given vaccine and hepatitis B immunoglobulin, within 12–24 post-delivery hours. A single center retrospective analysis of policies and practices to prevent mother-to-child transmission of HBV was carried out, to evaluate their adherence to HBV care guidelines. Paired maternal-infant medical records for consecutive live births, between January 2015 and December 2019, were reviewed at the AOU Città della Salute e Scienza di Torino, where a total of 235/35,506 babies (0.7%) were born to HBsAg positive mothers. Markers of active viral replication, i.e., HBV DNA level and/or HBeAg, were reported in only 66/235 (28%) of the mothers’ medical records. All newborns had immunoprophylaxis at birth: 61% at <12 h, 31% between 12 and 24 h, 7% between 24 and 36 h and 1% at >36 h. In 2019, two cases of vertical HBV transmission occurred, despite timely immunoprophylaxis, as their mothers’ viral load was detected too late for antiviral prophylaxis. Missed early identification of pregnant women with high viremia levels or late vaccinations may contribute to perinatal HBV infection. Immunoprophylaxis should be given to babies born to HBsAg positive mothers at the latest within 12 h. In Italy, policies aimed at achieving the WHO 2030 goal of eliminating viral hepatitis should be further implemented.

In patients with SarS-CoV2 and chronic Hepatitis B (HBV) co-infection liver injury is associated with a worse prognosis. We report a case of acute chronic liver failure (ACLF) with encephalopathy due to HBV reactivation during COVID-19 with undetectable INR. Thromboelastography showed a profile consistent with a prothrombotic state so INR was not a reliable marker of liver function until plasma infusion. After plasma infusion, indeed, an imbalance of hepatic function was shown by an underlying INR prolongation that was consistent with an ACLF.

Anti-TNF antibodies have become a first-line therapy in moderate-to-severe inflammatory bowel diseases. However, there may be some rare paradoxical events and those affecting joints causing severe symptoms need a scrupulous differential diagnosis. When these events occur, it may be necessary to discontinue treatment and shift to another drug class. Herein, we report the case of a 15-year-old boy affected by Crohn’s disease, who developed a paradoxical reaction after the second dose of infliximab. Clinical remission was achieved shifting to budesonide and azathioprine and continuing maintenance therapy with azathioprine alone. To date, no other paradoxical events have occurred.

Background The prevention of perinatal Hepatitis B virus (HBV) is crucial to reach the WHO's challenge to eliminate viral hepatitis as public health threat by 2030. After diagnosing 2 infants infected by vertical transmission, a retrospective analysis of policies and practices to prevent HBV congenital infection was conducted to assess any potential risk. Methods Paired maternal-infant medical records between 2017 and 2019 were reviewed at A.O.U Città della Salute e Scienza di Torino, the italian hospital with the highest number of deliveries. Data included maternal HBSAg and coinfection (HIV, HCV) status and the administration of prophylaxis in newborns at risk. Other serologic markers of HBV maternal infection were not available. Results 132 (0,6%) newborns from HBsAg positive mothers were identified between 2017-2019 among 21143 newborns. In this group pre-natal HBSAg status was known in 127 (96,2%), the remaining were tested during the hospitalization. Regarding maternal coinfection 130 (98%) were tested for HIV (1 positive), only 60 (45.1%) for HCV (all negative). All newborns received immunoprophylaxis consisting in the administration of vaccination and immunoglobulin: 119 (89%) within 24 hours (63% within 12 hours), 12 (9%) between 24-36 hours and 2 (1,6%) after 36 hours. The 2 cases of vertical transmission, even if correctly vaccinated, show a vaccination failure of 1,5%. Conclusions Although most of the mothers were tested for HBSAg status and all newborns were given immunoprophylaxis, vaccination failure seems to explain the 2 cases of vertical transmission. Since the lack in early maternal serologic screening and the late vaccination time could increase the risk of HBV infection, to achieve WHO goal we suggest to implement a multidisciplinary pathway to identify HBV positive mothers, to treat in case of high viral load, to provide a timely immunoprophylaxis considering a early vaccination and to set up a structured postnatal serologic check for newborns at risk. Key messages Vaccination failure must be considered in the service organization, a structured postnatal serologic check for all newborns at risk should be implemented to detect potential vaccination failure. A multidisciplinary pathway to identify HBV positive mothers, with a full serological markers set, should be implemented to give a correct maternal therapy and newborn prophylaxis.