Sex trafficking is the fastest‐growing organized criminal activity. Trafficking organizations are driven by profit and provide a service due to existing demand. We examined the feasibility of applying risk assessment methods to understand the problem of sex trafficking from a systems perspective. Focusing on Indiana, we recruited and trained subject matter experts (SMEs) in risk assessment methodologies utilized in Six Sigma (SS); specifically Cause and Effect (C&E) Matrix and Failure Mode and Effects Analysis (FMEA). The research team developed a sex trafficking business process map (BPM) and prioritized activities by applying a C&E Matrix to identify the process steps with the potential for disruption. The most common failure modes (FMEA) identified by the SMEs included the trafficker or customer being caught followed by the victim being rescued. We conclude that an SS risk assessment approach is a viable framework in understanding the system of sex trafficking. Limitations and future research suggestions are discussed.