Background: Early diagnosis of SARS-CoV-2 infection is essential to reduce disease spread. Rapid antigen tests have not been sufficiently evaluated in asymptomatic patients to be used as massive population screening tools. Methods: Head-to-head evaluation of Roche SARS-CoV-2 Rapid Antigen Test and real-time reverse transcription polymerase chain reaction (RT-PCR) as SARS-CoV-2 screening tools performed in asymptomatic adults from a semi-closed community in University of Navarra (Spain) from November 2020 to January 2021. Sensitivity, specificity and predictive values were calculated using RT-PCR as reference method. Findings: Roche SARS-CoV-2 Rapid Antigen Test was performed on 2542 asymptomatic adults in a community with a SARS-CoV-2 incidence of 1¢93%. It showed a sensitivity of 71¢43% (CI 95%: 56¢74 À 83¢42) and a specificity of 99¢68% (CI 95%: 99¢37 -99¢86). Positive Predictive Value was 81¢4 (CI 95% 66¢6 À 91¢61) and Negative Predictive Value was 99¢44 (CI 95% 99¢06 À 99¢69). Test sensitivity was related to viral load, with higher sensitivity in RT-PCR cycle threshold (Ct) values under 25 (93¢75%, CI 95%: 71¢96 À 98¢93), that dropped to 29¢41% (CI 95%: 10¢31-55¢96) in RT-PCR Ct values above 25. Interpretation: This study suggests that rapid antigen tests are less effective in asymptomatic population, when compared with RT-PCR. Further studies are needed to evaluate different options to improve screenings based on rapid antigen test, such as the use of clinical questionnaires to select higher risk-participants, the confirmation of negative results with RT-PCR or the use of repetitive sequential testing.

Background The association between parental perception of child’s weight and their attitudes towards his/her dietary habits has not been reported yet. This study aimed to assess the association between parental underestimation of child’s weight and parental attitudes towards child’s dietary habits. Methods We conducted a cross-sectional analysis of SENDO cohort participants recruited between January 2015 and June 2020. All information was collected through online questionnaires completed by parents. We calculated crude and multivariable-adjusted odds ratio (OR) and 95% confidence intervals (CI) for unhealthy attitudes towards child’s dietary habits associated with parental underestimation of child’s weight. Results Sixteen percent of children in the SENDO project had parents who underestimated their weight. Parents who underestimated their child’s weight status were more likely to have unhealthy attitudes toward his/her dietary habits [OR 3.35; 95% CI (1.71–6.53)]. Conclusions Parental underestimation of child's weight was associated with unhealthy attitudes towards child’s dietary habits. Pediatricians and public health practitioners should pay attention to the parental perception of child’s weight to identify parents who underestimate it as an at-risk group in which to inquire about lifestyle and dietary habits.

No abstract