No abstract

Brazilian Propolis. -Compounds such as (I)-(III) are prepared and their cytotoxic properties are investigated. (IIa) shows significant selective activity (IC50 < 9 µg/ml). -(PISCO, L.; KORDIAN, M.; PESEKE, K.; FEIST, H.; MICHALIK, D.; ESTRADA, E.; CARVALHO, J.; HAMILTON, G.; RANDO, D.; QUINCOCES*, J.; Eur. J. Med. Chem. 41 (2006) 3, 401-407; Grupo Sint. Org., Univ. Bandeirante Sao Paulo, 02071 Sao Paulo, Brazil; Eng.) -K. Schneider 35-232

This work describes the synthesis, antinociceptive and anti-inflammatory effect of <i>O</i>-prenyl derivatives: <i>O</i>-prenyl derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) and 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (V1). Treatment with L1- or V1-produced antinociceptive effect on classical pain models: acetic acid abdominal contortions and formalin test (first and second phases), and in hot plate or tale flick models in mice without changing the locomotors performance, and anti-oedematogenic or anti-inflammatory effect <i>in vivo</i>: carrageenan-induced paw oedema and peritonitis in mice. In addition, L1 and V1 derivatives reduced nitric oxide production on RAW 264.7 cells stimulated with lipopolysaccharide without changing the cell viability. Taken together, our results show for the first time that L1 and V1 can produce antinociception and modulate inflammatory response when administered in mice