A new method for rapid late-stage fluorination using the cation pool technique is presented. Fluorination and no-carrier-added radiofluorination of methyl (phenylthio) acetate, methyl 2-(methylthio) acetate, and methyl 2-(ethylthio) acetate were performed. The carbocations formed through electrochemical oxidation were stabilized by using a divided electrochemical cell and 2,2,2-trifluoroethanol (TFE) as the solvent at −20 °C. At the end of electrolysis, either stable-isotope [19F]fluoride or no-carrier-added radioactive [18F]fluoride was added to the reaction mixture to form the fluorinated or radiofluorinated product.
It is well-established that race is a social construct that has little to no biological relevance in the absence of context such as the significant impact of the social, political, and environmental systems that contribute to health and health inequities. However, pharmacy school curricula often misrepresent race as the basis of disease diagnosis and reinforce race-based clinical guidelines without contextualization. Pharmacy schools, through the partnership of students and faculty, should 1) contextualize the mention of race and the differences in disease burden, and 2) provide evidence for race-based guidelines and clinical decision-making in education materials. In this way, we can work to halt the perpetuation of teaching bias to future healthcare professionals.
The Cover Feature illustrates radio‐labelling using a cation pool technique. This method provides a truly late‐stage fluorination reaction, maximizing radiochemical yield by minimizing decay through rapid reaction of the previously prepared cations with [18F] fluoride. More information can be found in the Communication by M. Balandeh et al. on page 3353 in Issue 22, 2018 (DOI: 10.1002/celc.201800973).
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