Introduction Over 8,000 Hispanic children die annually in the United States; yet, little is known about the end-of-life care utilized. The purpose of this study was to examine the children and family characteristics associated with end-of-life care for Hispanic children. Methods A sample of 370 Hispanic children was created, using the 2009-2010 California Medicaid data. The relationship between child and family characteristics and end-of-life care utilization (i.e., hospice enrollment, emergency room utilization, hospital admissions) was analyzed using multivariate regression. Results Pediatric hospice accessibility ( p< 0.05), palliative care policy (p <0.01), congenital anomalies (p <0.01), and cardiovascular conditions (p <0.01) were related to hospice enrollment. Usual source of care (p <0.001), functional status (p <0.001), palliative care policy (p <0.01), and private insurance (p <0.01) were associated with emergency room utilization; while usual source of care (p <0.001), cancer (p <0.001), and disability status (p <0.01) corresponded with hospital admissions. Conclusion Nursing practices aimed at engaging Hispanic families in their community are critical to end-of-life care utilization for Hispanic children.