No abstract

Objective: To investigate if differences in self-reported satisfaction with fertility clinics and doctors differ by race/ethnicity. Study Design: We used cross-sectional survey data from FertilityIQ online questionnaires completed by patients receiving U.S. fertility care from July 2015 to December 2020. Univariate and multivariate logistic and linear regression analyses performed to assess association of race/ethnicity on patient reported clinic and physician satisfaction. Results: Our total sample size included 21,472 patients (15,986 Caucasian, 1,856 Black, 1,780 LatinX, 771 East Asian, 619 South Asian, 273 Middle Eastern, 187 Native American self-reported). When adjusting for all confounders (demographic and patient satisfaction), we found that Black patients rated their doctors more highly (OR 1.30, 95% CI 1.04-1.62 p=0.022 logistic and Coef 0.082, 95% CI 0.013-0.15 p=0.02 linear), while other ethnic groups did not show significant differences compared to Caucasian patients. East Asians had borderline lower satisfaction with clinic satisfaction in logistic regression (OR 0.74 95% CI 0.55-1.00 p=0.05), while significant differences were not found for other ethnic groups for clinic satisfaction. Conclusions: In summary, some but not all minority groups differed in their self-reported perception of satisfaction with fertility clinic and doctors compared to Caucasian patients. Cultural differences towards surveys may contribute to some of these findings, and satisfaction by racial/ethnic group may also be modified by results of care.

MATERIALS AND METHODS: Protein expressions profile of eutopic endometrial tissues from participants with minimal/mild endometriosis in secretory phase were analyzed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) based proteomics with data-independent acquisition (DIA) workflow. Up-regulated endometrial receptivity associated markers were screened out after metformin treatment in paired endometria. Parallel reaction monitoring (PRM) and immunochemistry were used for validation these markers. Endometria of endometriosis mice model on day 4 of pseudopregnancy were used for measured above screened markers, LIF and integrin avb3 expression.RESULTS: Compared to baseline, 149 differentially expressed proteins were detected in the endometria after metformin therapy. Insulin-like growth factor-binding protein 7 (IGFBP-7), a-antitrypsin (AAT), apolipoprotein D (ApoD), Rho GDP-dissociation inhibitor 1 (Rho-GDI), brain form glycogen phosphorylase (PYGB) and Cathepsin B (CTSB) that associated with endometrial receptivity had up-regulated after metformin therapy (P<0.05); while the expressions of those protein had no significant change in non-received controls. Up-regulated expression of IGFBP-7 and ApoD had been validated by PRM. IGFBP-7 and integrinb3 were up-regulated after metformin treatment in endometria of endometriosis mice model during window of implantation.CONCLUSIONS: Our study revealed that metformin may ameliorate expression of proteins related to endometrial receptivity in women with minimal/mild endometriosis and endometriosis mice model. Metformin could be used as potentially novel therapy to improve endometrial receptivity of infertile women with endometriosis.

Objective: To investigate if differences in self-reported satisfaction with fertility clinics and doctors differ by race/ethnicity. Study Design: We used cross-sectional survey data from FertilityIQ online questionnaires completed by patients receiving U.S. fertility care from July 2015 to December 2020. Univariate and multivariate logistic and linear regression analyses performed to assess association of race/ethnicity on patient reported clinic and physician satisfaction.

No abstract